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Stereocontrolled access to thioisosteres of nucleoside di- and triphosphates.
Zhang HJ, Ociepa M, Nassir M, Zheng B, Lewicki SA, Salmaso V, Baburi H, Nagel J, Mirza S, Bueschbell B, Al-Hroub H, Perzanowska O, Lin Z, Schmidt MA, Eastgate MD, Jacobson KA, Müller CE, Kowalska J, Jemielity J, Baran PS. Zhang HJ, et al. Among authors: zheng b. Nat Chem. 2024 Feb;16(2):249-258. doi: 10.1038/s41557-023-01347-2. Epub 2023 Oct 19. Nat Chem. 2024. PMID: 37857844
Mild and Chemoselective Phosphorylation of Alcohols Using a Ψ-Reagent.
Ociepa M, Knouse KW, He D, Vantourout JC, Flood DT, Padial NM, Chen JS, Sanchez BB, Sturgell EJ, Zheng B, Qiu S, Schmidt MA, Eastgate MD, Baran PS. Ociepa M, et al. Among authors: zheng b. Org Lett. 2021 Dec 17;23(24):9337-9342. doi: 10.1021/acs.orglett.1c02736. Epub 2021 Sep 9. Org Lett. 2021. PMID: 34499517 Free PMC article.
Unlocking P(V): Reagents for chiral phosphorothioate synthesis.
Knouse KW, deGruyter JN, Schmidt MA, Zheng B, Vantourout JC, Kingston C, Mercer SE, Mcdonald IM, Olson RE, Zhu Y, Hang C, Zhu J, Yuan C, Wang Q, Park P, Eastgate MD, Baran PS. Knouse KW, et al. Among authors: zheng b. Science. 2018 Sep 21;361(6408):1234-1238. doi: 10.1126/science.aau3369. Epub 2018 Aug 2. Science. 2018. PMID: 30072577 Free PMC article.
P(III) vs P(V): A P(V) Reagent for Thiophosphoramidate Linkages and Application to an Asymmetric Synthesis of a Cyclic Dinucleotide STING Agonist.
Zheng B, Hang C, Zhu J, Purdum GE, Sezen-Edmonds M, Treitler DS, Yu M, Yuan C, Zhu Y, Freitag A, Guo S, Zhu G, Hritzko B, Paulson J, Shackman JG, He BL, Fu W, Tai HC, Ayers S, Park H, Eastgate MD, Cohen B, Rogers A, Wang Q, Schmidt MA. Zheng B, et al. J Org Chem. 2022 Feb 18;87(4):1934-1940. doi: 10.1021/acs.joc.1c01055. Epub 2021 Jul 7. J Org Chem. 2022. PMID: 34232659
A P(V) platform for oligonucleotide synthesis.
Huang Y, Knouse KW, Qiu S, Hao W, Padial NM, Vantourout JC, Zheng B, Mercer SE, Lopez-Ogalla J, Narayan R, Olson RE, Blackmond DG, Eastgate MD, Schmidt MA, McDonald IM, Baran PS. Huang Y, et al. Among authors: zheng b. Science. 2021 Sep 10;373(6560):1265-1270. doi: 10.1126/science.abi9727. Epub 2021 Sep 9. Science. 2021. PMID: 34516793 Free PMC article.
6,105 results