Zheleva D - Search Results

1

Implementing Patient-Derived Xenografts to Assess the Effectiveness of Cyclin-Dependent Kinase Inhibitors in Glioblastoma.

Noonan JJ, Jarzabek M, Lincoln FA, Cavanagh BL, Pariag AR, Juric V, Young LS, Ligon KL, Jahns H, Zheleva D, Prehn JHM, Rehm M, Byrne AT, Murphy BM. Noonan JJ, et al. Among authors: zheleva d. Cancers (Basel). 2019 Dec 12;11(12):2005. doi: 10.3390/cancers11122005. Cancers (Basel). 2019. PMID: 31842413 Free PMC article.

2

In vitro and in vivo antitumor properties of the cyclin dependent kinase inhibitor CYC202 (R-roscovitine).

McClue SJ, Blake D, Clarke R, Cowan A, Cummings L, Fischer PM, MacKenzie M, Melville J, Stewart K, Wang S, Zhelev N, Zheleva D, Lane DP. McClue SJ, et al. Among authors: zheleva d. Int J Cancer. 2002 Dec 10;102(5):463-8. doi: 10.1002/ijc.10738. Int J Cancer. 2002. PMID: 12432547 Free article.

3

Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.

McInnes C, Andrews MJ, Zheleva DI, Lane DP, Fischer PM. McInnes C, et al. Curr Med Chem Anticancer Agents. 2003 Jan;3(1):57-69. doi: 10.2174/1568011033353506. Curr Med Chem Anticancer Agents. 2003. PMID: 12678915 Review.

4

Cyclin-dependent kinase inhibitor fadraciclib (CYC065) depletes anti-apoptotic protein and synergizes with venetoclax in primary chronic lymphocytic leukemia cells.

Chen R, Chen Y, Xiong P, Zheleva D, Blake D, Keating MJ, Wierda WG, Plunkett W. Chen R, et al. Among authors: zheleva d. Leukemia. 2022 Jun;36(6):1596-1608. doi: 10.1038/s41375-022-01553-w. Epub 2022 Apr 5. Leukemia. 2022. PMID: 35383271 Free PMC article.

5

Fadraciclib (CYC065), a novel CDK inhibitor, targets key pro-survival and oncogenic pathways in cancer.

Frame S, Saladino C, MacKay C, Atrash B, Sheldrake P, McDonald E, Clarke PA, Workman P, Blake D, Zheleva D. Frame S, et al. Among authors: zheleva d. PLoS One. 2020 Jul 9;15(7):e0234103. doi: 10.1371/journal.pone.0234103. eCollection 2020. PLoS One. 2020. PMID: 32645016 Free PMC article.

6

Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design.

Kontopidis G, Wu SY, Zheleva DI, Taylor P, McInnes C, Lane DP, Fischer PM, Walkinshaw MD. Kontopidis G, et al. Among authors: zheleva di. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1871-6. doi: 10.1073/pnas.0406540102. Epub 2005 Jan 28. Proc Natl Acad Sci U S A. 2005. PMID: 15681588 Free PMC article.

7

Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A.

Zheleva DI, McInnes C, Gavine AL, Zhelev NZ, Fischer PM, Lane DP. Zheleva DI, et al. J Pept Res. 2002 Nov;60(5):257-70. doi: 10.1034/j.1399-3011.2002.21014.x. J Pept Res. 2002. PMID: 12383116

8

Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitors.

Wang S, Midgley CA, Scaërou F, Grabarek JB, Griffiths G, Jackson W, Kontopidis G, McClue SJ, McInnes C, Meades C, Mezna M, Plater A, Stuart I, Thomas MP, Wood G, Clarke RG, Blake DG, Zheleva DI, Lane DP, Jackson RC, Glover DM, Fischer PM. Wang S, et al. J Med Chem. 2010 Jun 10;53(11):4367-78. doi: 10.1021/jm901913s. J Med Chem. 2010. PMID: 20462263

9

2-Anilino-4-(thiazol-5-yl)pyrimidine CDK inhibitors: synthesis, SAR analysis, X-ray crystallography, and biological activity.

Wang S, Meades C, Wood G, Osnowski A, Anderson S, Yuill R, Thomas M, Mezna M, Jackson W, Midgley C, Griffiths G, Fleming I, Green S, McNae I, Wu SY, McInnes C, Zheleva D, Walkinshaw MD, Fischer PM. Wang S, et al. Among authors: zheleva d. J Med Chem. 2004 Mar 25;47(7):1662-75. doi: 10.1021/jm0309957. J Med Chem. 2004. PMID: 15027857

10

Insights into cyclin groove recognition: complex crystal structures and inhibitor design through ligand exchange.

Kontopidis G, Andrews MJ, McInnes C, Cowan A, Powers H, Innes L, Plater A, Griffiths G, Paterson D, Zheleva DI, Lane DP, Green S, Walkinshaw MD, Fischer PM. Kontopidis G, et al. Among authors: zheleva di. Structure. 2003 Dec;11(12):1537-46. doi: 10.1016/j.str.2003.11.006. Structure. 2003. PMID: 14656438 Free article.

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