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Enhancing the expression of the unspecific peroxygenase in Komagataella phaffii through a combination strategy.
Zhao LX, Zou SP, Shen Q, Xue YP, Zheng YG. Zhao LX, et al. Appl Microbiol Biotechnol. 2024 May 6;108(1):320. doi: 10.1007/s00253-024-13166-7. Appl Microbiol Biotechnol. 2024. PMID: 38709366 Free PMC article.
KEY POINTS: The secretion of the catalytic domain of PaDa-I can be significantly enhanced through increasing gene copy numbers and co-expressing of protein disulfide isomerase. After optimizing the culture conditions, the volumetric enzyme activity can reach 117.3 U/mL, us …
KEY POINTS: The secretion of the catalytic domain of PaDa-I can be significantly enhanced through increasing gene copy numbers and co …
Genotypic-phenotypic landscape computation based on first principle and deep learning.
Liu Y, Luo Y, Lu X, Gao H, He R, Zhang X, Zhang X, Li Y. Liu Y, et al. Brief Bioinform. 2024 Mar 27;25(3):bbae191. doi: 10.1093/bib/bbae191. Brief Bioinform. 2024. PMID: 38701420 Free PMC article.
Accordingly, following the calculation path of the P-E theorem, we accurately obtained the basic reproduction number (${R}_0$) of SARS-CoV-2 from first principles, quantitatively linked immune escape to viral fitness and plotted the genotype-fitness landscape. ...
Accordingly, following the calculation path of the P-E theorem, we accurately obtained the basic reproduction number (${R}_0$) of SAR …
967 results