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Coronaviruses exploit a host cysteine-aspartic protease for replication.
Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, Shi J, Chai Y, Yuen TT, Hu B, Li C, Zhao X, Wang Y, Huang X, Lee KS, Luo C, Cai JP, Poon VK, Chan CC, Zhang AJ, Yuan S, Sit KY, Foo DC, Au WK, Wong KK, Zhou J, Kok KH, Jin DY, Chan JF, Yuen KY. Chu H, et al. Among authors: zhao x. Nature. 2022 Sep;609(7928):785-792. doi: 10.1038/s41586-022-05148-4. Epub 2022 Aug 3. Nature. 2022. PMID: 35922005
SREBP-dependent lipidomic reprogramming as a broad-spectrum antiviral target.
Yuan S, Chu H, Chan JF, Ye ZW, Wen L, Yan B, Lai PM, Tee KM, Huang J, Chen D, Li C, Zhao X, Yang D, Chiu MC, Yip C, Poon VK, Chan CC, Sze KH, Zhou J, Chan IH, Kok KH, To KK, Kao RY, Lau JY, Jin DY, Perlman S, Yuen KY. Yuan S, et al. Among authors: zhao x. Nat Commun. 2019 Jan 10;10(1):120. doi: 10.1038/s41467-018-08015-x. Nat Commun. 2019. PMID: 30631056 Free PMC article.
Infection of bat and human intestinal organoids by SARS-CoV-2.
Zhou J, Li C, Liu X, Chiu MC, Zhao X, Wang D, Wei Y, Lee A, Zhang AJ, Chu H, Cai JP, Yip CC, Chan IH, Wong KK, Tsang OT, Chan KH, Chan JF, To KK, Chen H, Yuen KY. Zhou J, et al. Among authors: zhao x. Nat Med. 2020 Jul;26(7):1077-1083. doi: 10.1038/s41591-020-0912-6. Epub 2020 May 13. Nat Med. 2020. PMID: 32405028
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Is an Important Surface Attachment Factor That Facilitates Entry of Middle East Respiratory Syndrome Coronavirus.
Chan CM, Chu H, Wang Y, Wong BH, Zhao X, Zhou J, Yang D, Leung SP, Chan JF, Yeung ML, Yan J, Lu G, Gao GF, Yuen KY. Chan CM, et al. Among authors: zhao x. J Virol. 2016 Sep 29;90(20):9114-27. doi: 10.1128/JVI.01133-16. Print 2016 Oct 15. J Virol. 2016. PMID: 27489282 Free PMC article.
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