Zhao T - Search Results

1

Design, synthesis and biological evaluation of KRAS^G12C-PROTACs.

Zhang X, Zhao T, Sun M, Li P, Lai M, Xie L, Chen J, Ding J, Xie H, Zhou J, Zhang H. Zhang X, et al. Among authors: zhao t. Bioorg Med Chem. 2023 Jan 15;78:117153. doi: 10.1016/j.bmc.2023.117153. Epub 2023 Jan 4. Bioorg Med Chem. 2023. PMID: 36621179

2

Design, synthesis and preliminary SAR studies of novel N-arylmethyl substituted piperidine-linked aniline derivatives as potent HIV-1 NNRTIs.

Zhang L, Zhan P, Chen X, Li Z, Xie Z, Zhao T, Liu H, De Clercq E, Pannecouque C, Balzarini J, Liu X. Zhang L, et al. Among authors: zhao t. Bioorg Med Chem. 2014 Jan 1;22(1):633-42. doi: 10.1016/j.bmc.2013.10.033. Epub 2013 Nov 6. Bioorg Med Chem. 2014. PMID: 24275349

3

Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors.

Li P, Cai S, Zhao T, Xu L, Guan D, Li J, Zhou J, Zhang H. Li P, et al. Among authors: zhao t. Bioorg Med Chem Lett. 2021 Dec 1;53:128409. doi: 10.1016/j.bmcl.2021.128409. Epub 2021 Oct 7. Bioorg Med Chem Lett. 2021. PMID: 34628036

4

Corrigendum to "Design, synthesis and biological evaluation of macrocyclic derivatives as TRK inhibitors" [Bioorg. Med. Chem. Lett. 53 (2021) 128409].

Li P, Cai S, Zhao T, Xu L, Guan D, Li J, Zhou J, Zhang H. Li P, et al. Among authors: zhao t. Bioorg Med Chem Lett. 2022 Jan 15;56:128502. doi: 10.1016/j.bmcl.2021.128502. Epub 2021 Dec 11. Bioorg Med Chem Lett. 2022. PMID: 34906405 No abstract available.

5

1-Hydroxypyrido[2,3-d]pyrimidin-2(1H)-ones as novel selective HIV integrase inhibitors obtained via privileged substructure-based compound libraries.

Gao P, Zhang L, Sun L, Huang T, Tan J, Zhang J, Zhou Z, Zhao T, Menéndez-Arias L, Pannecouque C, Clercq E, Zhan P, Liu X. Gao P, et al. Among authors: zhao t. Bioorg Med Chem. 2017 Oct 15;25(20):5779-5789. doi: 10.1016/j.bmc.2017.09.006. Epub 2017 Sep 8. Bioorg Med Chem. 2017. PMID: 28951095

6

Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel.

Kang D, Ruiz FX, Feng D, Pilch A, Zhao T, Wei F, Wang Z, Sun Y, Fang Z, De Clercq E, Pannecouque C, Arnold E, Liu X, Zhan P. Kang D, et al. Among authors: zhao t. J Med Chem. 2020 Feb 13;63(3):1298-1312. doi: 10.1021/acs.jmedchem.9b01769. Epub 2020 Jan 24. J Med Chem. 2020. PMID: 31935327 Free PMC article.

7

Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability.

Zhao T, Meng Q, Sun Z, Chen Y, Ai W, Zhao Z, Kang D, Dong Y, Liang R, Wu T, Pang J, Liu X, Zhan P. Zhao T, et al. Among authors: zhao z. J Med Chem. 2020 Oct 8;63(19):10829-10854. doi: 10.1021/acs.jmedchem.0c00223. Epub 2020 Sep 21. J Med Chem. 2020. PMID: 32897699

8

Discovery of Novel Bicyclic Imidazolopyridine-Containing Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Improved Efficacy and Favorable Druggability.

Zhao T, Zhang J, Tao Y, Liao H, Zhao F, Liang R, Shi X, Zhang Z, Ji J, Wu T, Pang J, Liu X, Zhan P. Zhao T, et al. Among authors: zhao f. J Med Chem. 2022 Mar 10;65(5):4218-4237. doi: 10.1021/acs.jmedchem.1c02057. Epub 2022 Jan 27. J Med Chem. 2022. PMID: 35084182

9

Design, synthesis and activity evaluation of novel lesinurad analogues containing thienopyrimidinone or pyridine substructure as human urate transporter 1 inhibitors.

Zhang J, Dong Y, Gao S, Zhang X, Liao H, Shi X, Zhang Z, Zhao T, Liang R, Qi D, Wu T, Pang J, Liu X, Zhan P. Zhang J, et al. Among authors: zhao t. Eur J Med Chem. 2022 Dec 15;244:114816. doi: 10.1016/j.ejmech.2022.114816. Epub 2022 Oct 4. Eur J Med Chem. 2022. PMID: 36219903

10

Discovery of a Novel Thienopyrimidine Compound as a Urate Transporter 1 and Glucose Transporter 9 Dual Inhibitor with Improved Efficacy and Favorable Druggability.

Shi X, Zhao T, Wang S, Xu S, Liao H, Gao S, Gao Z, Zhang J, Qi D, Zhang Z, Zheng F, Wang Y, Wang Z, Yang M, Yang Q, Yi F, Pang J, Liu X, Zhan P. Shi X, et al. Among authors: zhao t. J Med Chem. 2024 Mar 28;67(6):5032-5052. doi: 10.1021/acs.jmedchem.4c00136. Epub 2024 Mar 14. J Med Chem. 2024. PMID: 38482820

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