Zhao L - Search Results

1

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy.

Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C; Alzheimer’s Disease Neuroimaging Initiative; Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM. Shi Y, et al. Among authors: zhao l. Nature. 2017 Sep 28;549(7673):523-527. doi: 10.1038/nature24016. Epub 2017 Sep 20. Nature. 2017. PMID: 28959956 Free PMC article.

2

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.

Zhao L, Gottesdiener AJ, Parmar M, Li M, Kaminsky SM, Chiuchiolo MJ, Sondhi D, Sullivan PM, Holtzman DM, Crystal RG, Paul SM. Zhao L, et al. Neurobiol Aging. 2016 Aug;44:159-172. doi: 10.1016/j.neurobiolaging.2016.04.020. Epub 2016 Apr 30. Neurobiol Aging. 2016. PMID: 27318144

3

Vectored Intracerebral Immunization with the Anti-Tau Monoclonal Antibody PHF1 Markedly Reduces Tau Pathology in Mutant Tau Transgenic Mice.

Liu W, Zhao L, Blackman B, Parmar M, Wong MY, Woo T, Yu F, Chiuchiolo MJ, Sondhi D, Kaminsky SM, Crystal RG, Paul SM. Liu W, et al. Among authors: zhao l. J Neurosci. 2016 Dec 7;36(49):12425-12435. doi: 10.1523/JNEUROSCI.2016-16.2016. J Neurosci. 2016. PMID: 27927959 Free PMC article.

4

Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function.

Koizumi K, Hattori Y, Ahn SJ, Buendia I, Ciacciarelli A, Uekawa K, Wang G, Hiller A, Zhao L, Voss HU, Paul SM, Schaffer C, Park L, Iadecola C. Koizumi K, et al. Among authors: zhao l. Nat Commun. 2018 Sep 19;9(1):3816. doi: 10.1038/s41467-018-06301-2. Nat Commun. 2018. PMID: 30232327 Free PMC article.

5

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's Disease.

Rosenberg JB, Kaplitt MG, De BP, Chen A, Flagiello T, Salami C, Pey E, Zhao L, Ricart Arbona RJ, Monette S, Dyke JP, Ballon DJ, Kaminsky SM, Sondhi D, Petsko GA, Paul SM, Crystal RG. Rosenberg JB, et al. Among authors: zhao l. Hum Gene Ther Clin Dev. 2018 Mar;29(1):24-47. doi: 10.1089/humc.2017.231. Epub 2018 Mar 13. Hum Gene Ther Clin Dev. 2018. PMID: 29409358 Free PMC article.

6

Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice.

Hunter JM, Cirrito JR, Restivo JL, Kinley RD, Sullivan PM, Holtzman DM, Koger D, Delong C, Lin S, Zhao L, Liu F, Bales K, Paul SM. Hunter JM, et al. Among authors: zhao l. Brain Res. 2012 Jul 27;1467:120-32. doi: 10.1016/j.brainres.2012.05.048. Epub 2012 Jun 5. Brain Res. 2012. PMID: 22682924

7

tPA Deficiency Underlies Neurovascular Coupling Dysfunction by Amyloid-β.

Park L, Zhou J, Koizumi K, Wang G, Anfray A, Ahn SJ, Seo J, Zhou P, Zhao L, Paul S, Anrather J, Iadecola C. Park L, et al. Among authors: zhao l. J Neurosci. 2020 Oct 14;40(42):8160-8173. doi: 10.1523/JNEUROSCI.1140-20.2020. Epub 2020 Sep 14. J Neurosci. 2020. PMID: 32928888 Free PMC article.

8

Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism.

Zhao L, Lin S, Bales KR, Gelfanova V, Koger D, Delong C, Hale J, Liu F, Hunter JM, Paul SM. Zhao L, et al. J Neurosci. 2009 Mar 18;29(11):3603-12. doi: 10.1523/JNEUROSCI.5302-08.2009. J Neurosci. 2009. PMID: 19295164 Free PMC article.

9

Scara1 deficiency impairs clearance of soluble amyloid-β by mononuclear phagocytes and accelerates Alzheimer's-like disease progression.

Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J. Frenkel D, et al. Among authors: zhao l. Nat Commun. 2013;4:2030. doi: 10.1038/ncomms3030. Nat Commun. 2013. PMID: 23799536 Free PMC article.

10

CD33 in Alzheimer's Disease - Biology, Pathogenesis, and Therapeutics: A Mini-Review.

Zhao L. Zhao L. Gerontology. 2019;65(4):323-331. doi: 10.1159/000492596. Epub 2018 Dec 12. Gerontology. 2019. PMID: 30541012 Free article. Review.

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