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Autologous humanized PDX modeling for immuno-oncology recapitulates features of the human tumor microenvironment.
Chiorazzi M, Martinek J, Krasnick B, Zheng Y, Robbins KJ, Qu R, Kaufmann G, Skidmore Z, Juric M, Henze LA, Brösecke F, Adonyi A, Zhao J, Shan L, Sefik E, Mudd J, Bi Y, Goedegebuure SP, Griffith M, Griffith O, Oyedeji A, Fertuzinhos S, Garcia-Milian R, Boffa D, Detterbeck F, Dhanasopon A, Blasberg J, Judson B, Gettinger S, Politi K, Kluger Y, Palucka K, Fields RC, Flavell RA. Chiorazzi M, et al. Among authors: zhao j. J Immunother Cancer. 2023 Jul;11(7):e006921. doi: 10.1136/jitc-2023-006921. J Immunother Cancer. 2023. PMID: 37487666 Free PMC article.
Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells.
Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Zhu S, et al. Among authors: zhao j, zhao y. Nature. 2017 Jun 29;546(7660):667-670. doi: 10.1038/nature22967. Epub 2017 Jun 21. Nature. 2017. PMID: 28636595 Free PMC article.
m6A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways.
Li HB, Tong J, Zhu S, Batista PJ, Duffy EE, Zhao J, Bailis W, Cao G, Kroehling L, Chen Y, Wang G, Broughton JP, Chen YG, Kluger Y, Simon MD, Chang HY, Yin Z, Flavell RA. Li HB, et al. Among authors: zhao j. Nature. 2017 Aug 17;548(7667):338-342. doi: 10.1038/nature23450. Epub 2017 Aug 9. Nature. 2017. PMID: 28792938 Free PMC article.
KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.
Herndler-Brandstetter D, Ishigame H, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA. Herndler-Brandstetter D, et al. Among authors: zhao j. Immunity. 2018 Apr 17;48(4):716-729.e8. doi: 10.1016/j.immuni.2018.03.015. Epub 2018 Apr 3. Immunity. 2018. PMID: 29625895 Free PMC article.
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.
Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S. Song Y, et al. Among authors: zhao j. Nat Commun. 2019 Jan 21;10(1):366. doi: 10.1038/s41467-018-08166-x. Nat Commun. 2019. PMID: 30664659 Free PMC article.
Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function.
Bailis W, Shyer JA, Zhao J, Canaveras JCG, Al Khazal FJ, Qu R, Steach HR, Bielecki P, Khan O, Jackson R, Kluger Y, Maher LJ 3rd, Rabinowitz J, Craft J, Flavell RA. Bailis W, et al. Among authors: zhao j. Nature. 2019 Jul;571(7765):403-407. doi: 10.1038/s41586-019-1311-3. Epub 2019 Jun 19. Nature. 2019. PMID: 31217581 Free PMC article.
Effector TH17 Cells Give Rise to Long-Lived TRM Cells that Are Essential for an Immediate Response against Bacterial Infection.
Amezcua Vesely MC, Pallis P, Bielecki P, Low JS, Zhao J, Harman CCD, Kroehling L, Jackson R, Bailis W, Licona-Limón P, Xu H, Iijima N, Pillai PS, Kaplan DH, Weaver CT, Kluger Y, Kowalczyk MS, Iwasaki A, Pereira JP, Esplugues E, Gagliani N, Flavell RA. Amezcua Vesely MC, et al. Among authors: zhao j. Cell. 2019 Aug 22;178(5):1176-1188.e15. doi: 10.1016/j.cell.2019.07.032. Cell. 2019. PMID: 31442406 Free PMC article.
Enteric Nervous System-Derived IL-18 Orchestrates Mucosal Barrier Immunity.
Jarret A, Jackson R, Duizer C, Healy ME, Zhao J, Rone JM, Bielecki P, Sefik E, Roulis M, Rice T, Sivanathan KN, Zhou T, Solis AG, Honcharova-Biletska H, Vélez K, Hartner S, Low JS, Qu R, de Zoete MR, Palm NW, Ring AM, Weber A, Moor AE, Kluger Y, Nowarski R, Flavell RA. Jarret A, et al. Among authors: zhao j. Cell. 2020 Jan 9;180(1):50-63.e12. doi: 10.1016/j.cell.2019.12.016. Cell. 2020. PMID: 31923399 Free PMC article.
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