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Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.
Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J 3rd, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY. Bertero T, et al. Among authors: zhao j. J Clin Invest. 2016 Sep 1;126(9):3313-35. doi: 10.1172/JCI86387. Epub 2016 Aug 22. J Clin Invest. 2016. PMID: 27548520 Free PMC article.
Specific circulating microRNAs display dose-dependent responses to variable intensity and duration of endurance exercise.
Ramos AE, Lo C, Estephan LE, Tai YY, Tang Y, Zhao J, Sugahara M, Gorcsan J 3rd, Brown MG, Lieberman DE, Chan SY, Baggish AL. Ramos AE, et al. Among authors: zhao j. Am J Physiol Heart Circ Physiol. 2018 Aug 1;315(2):H273-H283. doi: 10.1152/ajpheart.00741.2017. Epub 2018 Mar 30. Am J Physiol Heart Circ Physiol. 2018. PMID: 29600898 Free PMC article.
BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension.
Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J 3rd, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY. Yu Q, et al. Among authors: zhao j. Circulation. 2019 May 7;139(19):2238-2255. doi: 10.1161/CIRCULATIONAHA.118.035889. Circulation. 2019. PMID: 30759996 Free PMC article.
SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension.
Sun W, Tang Y, Tai YY, Handen A, Zhao J, Speyer G, Al Aaraj Y, Watson A, Romanelli ME, Sembrat J, Rojas M, Simon MA, Zhang Y, Lee J, Xiong Z, Dutta P, Vasamsetti SB, McNamara D, McVerry B, McTiernan CF, Sciurba FC, Kim S, Smith KA, Mazurek JA, Han Y, Vaidya A, Nouraie SM, Kelly NJ, Chan SY. Sun W, et al. Among authors: zhao j. JACC Basic Transl Sci. 2020 Nov 4;5(11):1073-1092. doi: 10.1016/j.jacbts.2020.08.010. eCollection 2020 Nov. JACC Basic Transl Sci. 2020. PMID: 33294740 Free PMC article.
Interleukin-6 mediates neutrophil mobilization from bone marrow in pulmonary hypertension.
Florentin J, Zhao J, Tai YY, Vasamsetti SB, O'Neil SP, Kumar R, Arunkumar A, Watson A, Sembrat J, Bullock GC, Sanders L, Kassa B, Rojas M, Graham BB, Chan SY, Dutta P. Florentin J, et al. Among authors: zhao j. Cell Mol Immunol. 2021 Feb;18(2):374-384. doi: 10.1038/s41423-020-00608-1. Epub 2021 Jan 8. Cell Mol Immunol. 2021. PMID: 33420357 Free PMC article.
Frataxin deficiency promotes endothelial senescence in pulmonary hypertension.
Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock CC, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson AM, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar AU, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY. Culley MK, et al. Among authors: zhao j. J Clin Invest. 2021 Jun 1;131(11):e136459. doi: 10.1172/JCI136459. J Clin Invest. 2021. PMID: 33905372 Free PMC article.
Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension.
Negi V, Yang J, Speyer G, Pulgarin A, Handen A, Zhao J, Tai YY, Tang Y, Culley MK, Yu Q, Forsythe P, Gorelova A, Watson AM, Al Aaraj Y, Satoh T, Sharifi-Sanjani M, Rajaratnam A, Sembrat J, Provencher S, Yin X, Vargas SO, Rojas M, Bonnet S, Torrino S, Wagner BK, Schreiber SL, Dai M, Bertero T, Al Ghouleh I, Kim S, Chan SY. Negi V, et al. Among authors: zhao j. Sci Adv. 2021 Oct 22;7(43):eabh3794. doi: 10.1126/sciadv.abh3794. Epub 2021 Oct 20. Sci Adv. 2021. PMID: 34669463 Free PMC article.
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