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APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.
Zhao J, Fu Y, Yamazaki Y, Ren Y, Davis MD, Liu CC, Lu W, Wang X, Chen K, Cherukuri Y, Jia L, Martens YA, Job L, Shue F, Nguyen TT, Younkin SG, Graff-Radford NR, Wszolek ZK, Brafman DA, Asmann YW, Ertekin-Taner N, Kanekiyo T, Bu G. Zhao J, et al. Nat Commun. 2020 Nov 2;11(1):5540. doi: 10.1038/s41467-020-19264-0. Nat Commun. 2020. PMID: 33139712 Free PMC article.
Frontotemporal dementia-associated N279K tau mutant disrupts subcellular vesicle trafficking and induces cellular stress in iPSC-derived neural stem cells.
Wren MC, Zhao J, Liu CC, Murray ME, Atagi Y, Davis MD, Fu Y, Okano HJ, Ogaki K, Strongosky AJ, Tacik P, Rademakers R, Ross OA, Dickson DW, Wszolek ZK, Kanekiyo T, Bu G. Wren MC, et al. Among authors: zhao j. Mol Neurodegener. 2015 Sep 15;10:46. doi: 10.1186/s13024-015-0042-7. Mol Neurodegener. 2015. PMID: 26373282 Free PMC article.
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