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α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson's disease.
Cole TA, Zhao H, Collier TJ, Sandoval I, Sortwell CE, Steece-Collier K, Daley BF, Booms A, Lipton J, Welch M, Berman M, Jandreski L, Graham D, Weihofen A, Celano S, Schulz E, Cole-Strauss A, Luna E, Quach D, Mohan A, Bennett CF, Swayze EE, Kordasiewicz HB, Luk KC, Paumier KL. Cole TA, et al. Among authors: zhao h. JCI Insight. 2021 Mar 8;6(5):e135633. doi: 10.1172/jci.insight.135633. JCI Insight. 2021. PMID: 33682798 Free PMC article.
Oligonucleotide therapy mitigates disease in spinocerebellar ataxia type 3 mice.
McLoughlin HS, Moore LR, Chopra R, Komlo R, McKenzie M, Blumenstein KG, Zhao H, Kordasiewicz HB, Shakkottai VG, Paulson HL. McLoughlin HS, et al. Among authors: zhao h. Ann Neurol. 2018 Jul;84(1):64-77. doi: 10.1002/ana.25264. Epub 2018 Aug 6. Ann Neurol. 2018. PMID: 29908063 Free PMC article.
Antisense oligonucleotides extend survival of prion-infected mice.
Raymond GJ, Zhao HT, Race B, Raymond LD, Williams K, Swayze EE, Graffam S, Le J, Caron T, Stathopoulos J, O'Keefe R, Lubke LL, Reidenbach AG, Kraus A, Schreiber SL, Mazur C, Cabin DE, Carroll JB, Minikel EV, Kordasiewicz H, Caughey B, Vallabh SM. Raymond GJ, et al. Among authors: zhao ht. JCI Insight. 2019 Jul 30;5(16):e131175. doi: 10.1172/jci.insight.131175. JCI Insight. 2019. PMID: 31361599 Free PMC article.
An Antisense Oligonucleotide Leads to Suppressed Transcription of Hdac2 and Long-Term Memory Enhancement.
Poplawski SG, Garbett KA, McMahan RL, Kordasiewicz HB, Zhao H, Kennedy AJ, Goleva SB, Sanders TH, Motley ST, Swayze EE, Ecker DJ, Sweatt JD, Michael TP, Greer CB. Poplawski SG, et al. Among authors: zhao h. Mol Ther Nucleic Acids. 2020 Mar 6;19:1399-1412. doi: 10.1016/j.omtn.2020.01.027. Epub 2020 Feb 27. Mol Ther Nucleic Acids. 2020. PMID: 32160709 Free PMC article.
Prion protein lowering is a disease-modifying therapy across prion disease stages, strains and endpoints.
Minikel EV, Zhao HT, Le J, O'Moore J, Pitstick R, Graffam S, Carlson GA, Kavanaugh MP, Kriz J, Kim JB, Ma J, Wille H, Aiken J, McKenzie D, Doh-Ura K, Beck M, O'Keefe R, Stathopoulos J, Caron T, Schreiber SL, Carroll JB, Kordasiewicz HB, Cabin DE, Vallabh SM. Minikel EV, et al. Among authors: zhao ht. Nucleic Acids Res. 2020 Nov 4;48(19):10615-10631. doi: 10.1093/nar/gkaa616. Nucleic Acids Res. 2020. PMID: 32776089 Free PMC article.
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