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A novel E3 ubiquitin ligase TRAC-1 positively regulates T cell activation.
Zhao H, Li CC, Pardo J, Chu PC, Liao CX, Huang J, Dong JG, Zhou X, Huang Q, Huang B, Bennett MK, Molineaux SM, Lu H, Daniel-Issakani S, Payan DG, Masuda ES. Zhao H, et al. J Immunol. 2005 May 1;174(9):5288-97. doi: 10.4049/jimmunol.174.9.5288. J Immunol. 2005. PMID: 15843525
Systematic identification of regulatory proteins critical for T-cell activation.
Chu P, Pardo J, Zhao H, Li CC, Pali E, Shen MM, Qu K, Yu SX, Huang BC, Yu P, Masuda ES, Molineaux SM, Kolbinger F, Aversa G, de Vries J, Payan DG, Liao XC. Chu P, et al. Among authors: zhao h. J Biol. 2003;2(3):21. doi: 10.1186/1475-4924-2-21. Epub 2003 Sep 15. J Biol. 2003. PMID: 12974981 Free PMC article.
A novel role for p21-activated protein kinase 2 in T cell activation.
Chu PC, Wu J, Liao XC, Pardo J, Zhao H, Li C, Mendenhall MK, Pali E, Shen M, Yu S, Taylor VC, Aversa G, Molineaux S, Payan DG, Masuda ES. Chu PC, et al. Among authors: zhao h. J Immunol. 2004 Jun 15;172(12):7324-34. doi: 10.4049/jimmunol.172.12.7324. J Immunol. 2004. PMID: 15187108
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation.
Braselmann S, Taylor V, Zhao H, Wang S, Sylvain C, Baluom M, Qu K, Herlaar E, Lau A, Young C, Wong BR, Lovell S, Sun T, Park G, Argade A, Jurcevic S, Pine P, Singh R, Grossbard EB, Payan DG, Masuda ES. Braselmann S, et al. Among authors: zhao h. J Pharmacol Exp Ther. 2006 Dec;319(3):998-1008. doi: 10.1124/jpet.106.109058. Epub 2006 Aug 31. J Pharmacol Exp Ther. 2006. PMID: 16946104 Clinical Trial.
Design, synthesis of diaminopyrimidine inhibitors targeting IgE- and IgG-mediated activation of Fc receptor signaling.
Argade A, Bhamidipati S, Li H, Sylvain C, Clough J, Carroll D, Keim H, Braselmann S, Taylor V, Zhao H, Herlaar E, Issakani SD, Wong BR, Masuda ES, Payan DG, Singh R. Argade A, et al. Among authors: zhao h. Bioorg Med Chem Lett. 2015;25(10):2122-8. doi: 10.1016/j.bmcl.2015.03.072. Epub 2015 Apr 1. Bioorg Med Chem Lett. 2015. PMID: 25891105
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