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GPCR activation and GRK2 assembly by a biased intracellular agonist.
Duan J, Liu H, Zhao F, Yuan Q, Ji Y, Cai X, He X, Li X, Li J, Wu K, Gao T, Zhu S, Lin S, Wang MW, Cheng X, Yin W, Jiang Y, Yang D, Xu HE. Duan J, et al. Among authors: zhao f. Nature. 2023 Aug;620(7974):676-681. doi: 10.1038/s41586-023-06395-9. Epub 2023 Aug 2. Nature. 2023. PMID: 37532940
Structural basis for activation of the growth hormone-releasing hormone receptor.
Zhou F, Zhang H, Cong Z, Zhao LH, Zhou Q, Mao C, Cheng X, Shen DD, Cai X, Ma C, Wang Y, Dai A, Zhou Y, Sun W, Zhao F, Zhao S, Jiang H, Jiang Y, Yang D, Eric Xu H, Zhang Y, Wang MW. Zhou F, et al. Among authors: zhao f, zhao s, zhao lh. Nat Commun. 2020 Oct 15;11(1):5205. doi: 10.1038/s41467-020-18945-0. Nat Commun. 2020. PMID: 33060564 Free PMC article.
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.
Sun W, Chen LN, Zhou Q, Zhao LH, Yang D, Zhang H, Cong Z, Shen DD, Zhao F, Zhou F, Cai X, Chen Y, Zhou Y, Gadgaard S, van der Velden WJC, Zhao S, Jiang Y, Rosenkilde MM, Xu HE, Zhang Y, Wang MW. Sun W, et al. Among authors: zhao f, zhao s, zhao lh. Cell Res. 2020 Dec;30(12):1098-1108. doi: 10.1038/s41422-020-00442-0. Epub 2020 Nov 25. Cell Res. 2020. PMID: 33239759 Free PMC article.
Structural perspective of class B1 GPCR signaling.
Cong Z, Liang YL, Zhou Q, Darbalaei S, Zhao F, Feng W, Zhao L, Xu HE, Yang D, Wang MW. Cong Z, et al. Among authors: zhao f, zhao l. Trends Pharmacol Sci. 2022 Apr;43(4):321-334. doi: 10.1016/j.tips.2022.01.002. Epub 2022 Jan 22. Trends Pharmacol Sci. 2022. PMID: 35078643 Free article. Review.
Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors.
Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen LN, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang MW. Zhao F, et al. Among authors: zhao l. Nat Commun. 2022 Feb 25;13(1):1057. doi: 10.1038/s41467-022-28683-0. Nat Commun. 2022. PMID: 35217653 Free PMC article.
Structural basis for the tethered peptide activation of adhesion GPCRs.
Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schöneberg T, Liebscher I, Xu HE, Sun JP. Ping YQ, et al. Among authors: zhao f, zhao rj. Nature. 2022 Apr;604(7907):763-770. doi: 10.1038/s41586-022-04619-y. Epub 2022 Apr 13. Nature. 2022. PMID: 35418678
Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4).
Chen Y, Zhou Q, Wang J, Xu Y, Wang Y, Yan J, Wang Y, Zhu Q, Zhao F, Li C, Chen CW, Cai X, Bathgate RAD, Shen C, Eric Xu H, Yang D, Liu H, Wang MW. Chen Y, et al. Among authors: zhao f. Nat Commun. 2023 Jan 30;14(1):492. doi: 10.1038/s41467-023-36182-z. Nat Commun. 2023. PMID: 36717591 Free PMC article.
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