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Modeling disrupted synapse formation in wolfram syndrome using hESCs-derived neural cells and cerebral organoids identifies Riluzole as a therapeutic molecule.
Yuan F, Li Y, Hu R, Gong M, Chai M, Ma X, Cha J, Guo P, Yang K, Li M, Xu M, Ma Q, Su Q, Zhang C, Sheng Z, Wu H, Wang Y, Yuan W, Bian S, Shao L, Zhang R, Li K, Shao Z, Zhang ZN, Li W. Yuan F, et al. Among authors: zhang zn, zhang r, zhang c. Mol Psychiatry. 2023 Apr;28(4):1557-1570. doi: 10.1038/s41380-023-01987-3. Epub 2023 Feb 7. Mol Psychiatry. 2023. PMID: 36750736 Free PMC article.
Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma.
Wang X, Zhou R, Xiong Y, Zhou L, Yan X, Wang M, Li F, Xie C, Zhang Y, Huang Z, Ding C, Shi K, Li W, Liu Y, Cao Z, Zhang ZN, Zhou S, Chen C, Zhang Y, Chen L, Wang Y. Wang X, et al. Among authors: zhang zn, zhang y. Cell Res. 2021 Jun;31(6):684-702. doi: 10.1038/s41422-020-00451-z. Epub 2021 Jan 4. Cell Res. 2021. PMID: 33390587 Free PMC article.
ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes.
Ma Q, Xiao Y, Xu W, Wang M, Li S, Yang Z, Xu M, Zhang T, Zhang ZN, Hu R, Su Q, Yuan F, Xiao T, Wang X, He Q, Zhao J, Chen ZJ, Sheng Z, Chai M, Wang H, Shi W, Deng Q, Cheng X, Li W. Ma Q, et al. Among authors: zhang zn, zhang t. Nat Commun. 2022 Jul 16;13(1):4142. doi: 10.1038/s41467-022-31829-9. Nat Commun. 2022. PMID: 35842441 Free PMC article.
ISR inhibition reverses pancreatic β-cell failure in Wolfram syndrome models.
Hu R, Chen X, Su Q, Wang Z, Wang X, Gong M, Xu M, Le R, Gao Y, Dai P, Zhang ZN, Shao L, Li W. Hu R, et al. Among authors: zhang zn. Cell Death Differ. 2024 Mar;31(3):322-334. doi: 10.1038/s41418-024-01258-w. Epub 2024 Feb 6. Cell Death Differ. 2024. PMID: 38321214 Free PMC article.
225 results