Zhang ZM - Search Results

1

Efficient targeted oncogenic KRAS^G12C degradation via first reversible-covalent PROTAC.

Yang F, Wen Y, Wang C, Zhou Y, Zhou Y, Zhang ZM, Liu T, Lu X. Yang F, et al. Among authors: zhang zm. Eur J Med Chem. 2022 Feb 15;230:114088. doi: 10.1016/j.ejmech.2021.114088. Epub 2022 Jan 3. Eur J Med Chem. 2022. PMID: 35007863

2

Discovery of potent Pan-Raf inhibitors with increased solubility to overcome drug resistance.

Wang L, Zhang Y, Zhang Q, Zhu G, Zhang Z, Duan C, Lu T, Tang W. Wang L, et al. Eur J Med Chem. 2019 Feb 1;163:243-255. doi: 10.1016/j.ejmech.2018.11.033. Epub 2018 Nov 16. Eur J Med Chem. 2019. PMID: 30529543

3

Quinolone antibiotic derivatives as new selective Axl kinase inhibitors.

Tan L, Zhang Z, Gao D, Chan S, Luo J, Tu ZC, Zhang ZM, Ding K, Ren X, Lu X. Tan L, et al. Among authors: zhang z, zhang zm. Eur J Med Chem. 2019 Mar 15;166:318-327. doi: 10.1016/j.ejmech.2019.01.065. Epub 2019 Jan 30. Eur J Med Chem. 2019. PMID: 30731400

4

Design, synthesis and biological evaluation of 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-2-methylbenzamides as potent and selective pan-tropomyosin receptor kinase (TRK) inhibitors.

Cui S, Wang Y, Wang Y, Tang X, Ren X, Zhang L, Xu Y, Zhang Z, Zhang ZM, Lu X, Ding K. Cui S, et al. Among authors: zhang l, zhang z, zhang zm. Eur J Med Chem. 2019 Oct 1;179:470-482. doi: 10.1016/j.ejmech.2019.06.064. Epub 2019 Jun 25. Eur J Med Chem. 2019. PMID: 31271959

5

Pyrido[2, 3-d]pyrimidin-7(8H)-ones as new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors.

Huang M, Huang Y, Guo J, Yu L, Chang Y, Wang X, Luo J, Huang Y, Tu Z, Lu X, Xu Y, Zhang Z, Zhang Z, Ding K. Huang M, et al. Eur J Med Chem. 2021 Feb 5;211:113023. doi: 10.1016/j.ejmech.2020.113023. Epub 2020 Nov 16. Eur J Med Chem. 2021. PMID: 33248853

6

Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by "Inverse Drug Discovery".

Fan Y, Si H, Zhang Z, Zhong L, Sun H, Zhu C, Yin Z, Li H, Tang G, Yao SQ, Sun P, Zhang ZM, Ding K, Li Z. Fan Y, et al. Among authors: zhang z, zhang zm. J Med Chem. 2021 Nov 11;64(21):15582-15592. doi: 10.1021/acs.jmedchem.0c02024. Epub 2021 Oct 8. J Med Chem. 2021. PMID: 34623802

7

Proteome-wide Identification of Off-Targets of a Potent EGFR^L858R/T790M Mutant Inhibitor.

Lyu P, Jiang K, Zhou Y, Hu J, Chang Y, Zhang Z, Huang M, Zhang ZM, Ding K, Hao P, Lin L, Li Z. Lyu P, et al. Among authors: zhang z, zhang zm. ACS Med Chem Lett. 2022 Jan 19;13(2):292-297. doi: 10.1021/acsmedchemlett.1c00651. eCollection 2022 Feb 10. ACS Med Chem Lett. 2022. PMID: 35178185 Free PMC article.

8

Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance.

Wang Z, Wang J, Wang Y, Xiang S, Song X, Tu Z, Zhou Y, Zhang ZM, Zhang Z, Ding K, Lu X. Wang Z, et al. Among authors: zhang z, zhang zm. J Med Chem. 2022 Apr 28;65(8):6325-6337. doi: 10.1021/acs.jmedchem.2c00308. Epub 2022 Apr 15. J Med Chem. 2022. PMID: 35426680

9

Discovery of 8-(6-Methoxypyridin-3-yl)-1-(4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl)-1,5-dihydro-4H-[1,2,3]triazolo[4,5-c]quinolin-4-one (CQ211) as a Highly Potent and Selective RIOK2 Inhibitor.

Ouyang Y, Si H, Zhu C, Zhong L, Ma H, Li Z, Xiong H, Liu T, Liu Z, Zhang Z, Zhang ZM, Cai Q. Ouyang Y, et al. Among authors: zhang z, zhang zm. J Med Chem. 2022 Jun 9;65(11):7833-7842. doi: 10.1021/acs.jmedchem.2c00271. Epub 2022 May 18. J Med Chem. 2022. PMID: 35584513

10

Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors.

Li S, Zhang P, Xu F, Hu S, Liu J, Tan Y, Tu Z, Sun H, Zhang ZM, He QY, Sun P, Ding K, Li Z. Li S, et al. Among authors: zhang p, zhang zm. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26. J Med Chem. 2022. PMID: 35880853

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