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Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure.
Beltra JC, Abdel-Hakeem MS, Manne S, Zhang Z, Huang H, Kurachi M, Su L, Picton L, Ngiow SF, Muroyama Y, Casella V, Huang YJ, Giles JR, Mathew D, Belman J, Klapholz M, Decaluwe H, Huang AC, Berger SL, Garcia KC, Wherry EJ. Beltra JC, et al. Among authors: zhang z. Immunity. 2023 Dec 12;56(12):2699-2718.e11. doi: 10.1016/j.immuni.2023.11.005. Immunity. 2023. PMID: 38091951
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer.
Chen Z, Arai E, Khan O, Zhang Z, Ngiow SF, He Y, Huang H, Manne S, Cao Z, Baxter AE, Cai Z, Freilich E, Ali MA, Giles JR, Wu JE, Greenplate AR, Hakeem MA, Chen Q, Kurachi M, Nzingha K, Ekshyyan V, Mathew D, Wen Z, Speck NA, Battle A, Berger SL, Wherry EJ, Shi J. Chen Z, et al. Among authors: zhang z. Cell. 2021 Mar 4;184(5):1262-1280.e22. doi: 10.1016/j.cell.2021.02.019. Epub 2021 Feb 25. Cell. 2021. PMID: 33636129 Free PMC article.
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency.
Cao Z, Budinich KA, Huang H, Ren D, Lu B, Zhang Z, Chen Q, Zhou Y, Huang YH, Alikarami F, Kingsley MC, Lenard AK, Wakabayashi A, Khandros E, Bailis W, Qi J, Carroll MP, Blobel GA, Faryabi RB, Bernt KM, Berger SL, Shi J. Cao Z, et al. Among authors: zhang z. Mol Cell. 2021 Sep 2;81(17):3604-3622.e10. doi: 10.1016/j.molcel.2021.07.018. Epub 2021 Aug 5. Mol Cell. 2021. PMID: 34358447 Free PMC article.
p63 establishes epithelial enhancers at critical craniofacial development genes.
Lin-Shiao E, Lan Y, Welzenbach J, Alexander KA, Zhang Z, Knapp M, Mangold E, Sammons M, Ludwig KU, Berger SL. Lin-Shiao E, et al. Among authors: zhang z. Sci Adv. 2019 May 1;5(5):eaaw0946. doi: 10.1126/sciadv.aaw0946. eCollection 2019 May. Sci Adv. 2019. PMID: 31049400 Free PMC article.
An NK-like CAR T cell transition in CAR T cell dysfunction.
Good CR, Aznar MA, Kuramitsu S, Samareh P, Agarwal S, Donahue G, Ishiyama K, Wellhausen N, Rennels AK, Ma Y, Tian L, Guedan S, Alexander KA, Zhang Z, Rommel PC, Singh N, Glastad KM, Richardson MW, Watanabe K, Tanyi JL, O'Hara MH, Ruella M, Lacey SF, Moon EK, Schuster SJ, Albelda SM, Lanier LL, Young RM, Berger SL, June CH. Good CR, et al. Among authors: zhang z. Cell. 2021 Dec 9;184(25):6081-6100.e26. doi: 10.1016/j.cell.2021.11.016. Epub 2021 Dec 2. Cell. 2021. PMID: 34861191 Free PMC article.
Publisher Correction: SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry.
Kee J, Thudium S, Renner DM, Glastad K, Palozola K, Zhang Z, Li Y, Lan Y, Cesare J, Poleshko A, Kiseleva AA, Truitt R, Cardenas-Diaz FL, Zhang X, Xie X, Kotton DN, Alysandratos KD, Epstein JA, Shi PY, Yang W, Morrisey E, Garcia BA, Berger SL, Weiss SR, Korb E. Kee J, et al. Among authors: zhang z, zhang x. Nature. 2023 Jan;613(7945):E5. doi: 10.1038/s41586-022-05631-y. Nature. 2023. PMID: 36624294 Free PMC article. No abstract available.
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