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Tepotinib Inhibits Several Drug Efflux Transporters and Biotransformation Enzymes: The Role in Drug-Drug Interactions and Targeting Cytostatic Resistance In Vitro and Ex Vivo.
Vagiannis D, Budagaga Y, Morell A, Zhang Y, Novotná E, Skarka A, Kammerer S, Küpper JH, Hanke I, Rozkoš T, Hofman J. Vagiannis D, et al. Among authors: zhang y. Int J Mol Sci. 2021 Nov 3;22(21):11936. doi: 10.3390/ijms222111936. Int J Mol Sci. 2021. PMID: 34769363 Free PMC article.
Alisertib shows negligible potential for perpetrating pharmacokinetic drug-drug interactions on ABCB1, ABCG2 and cytochromes P450, but acts as dual-activity resistance modulator through the inhibition of ABCC1 transporter.
Vagiannis D, Zhang Y, Budagaga Y, Novotna E, Skarka A, Kammerer S, Küpper JH, Hofman J. Vagiannis D, et al. Among authors: zhang y. Toxicol Appl Pharmacol. 2022 Jan 1;434:115823. doi: 10.1016/j.taap.2021.115823. Epub 2021 Dec 9. Toxicol Appl Pharmacol. 2022. PMID: 34896433
The Interplay Between HIF-1α and EZH2 in Lung Cancer and Dual-Targeted Drug Therapy.
Wang J, Yang C, Xu H, Fan X, Jia L, Du Y, Liu S, Wang W, Zhang J, Zhang Y, Wang X, Liu Z, Bao J, Li S, Yang J, Wu C, Tang J, Chen G, Wang L. Wang J, et al. Among authors: zhang j, zhang y. Adv Sci (Weinh). 2024 Feb;11(7):e2303904. doi: 10.1002/advs.202303904. Epub 2023 Dec 10. Adv Sci (Weinh). 2024. PMID: 38072662 Free PMC article.
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