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TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
Lorenzana-Carrillo MA, Gopal K, Byrne NJ, Tejay S, Saleme B, Das SK, Zhang Y, Haromy A, Eaton F, Mendiola Pla M, Bowles DE, Dyck JRB, Ussher JR, Michelakis ED, Sutendra G. Lorenzana-Carrillo MA, et al. Among authors: zhang y. Sci Transl Med. 2022 Nov 2;14(669):eabm3565. doi: 10.1126/scitranslmed.abm3565. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322626
SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes.
Zhang Y, Zervopoulos SD, Boukouris AE, Lorenzana-Carrillo MA, Saleme B, Webster L, Liu Y, Haromy A, Tabatabaei Dakhili SA, Ussher JR, Sutendra G, Michelakis ED. Zhang Y, et al. J Am Heart Assoc. 2021 Dec 7;10(23):e020451. doi: 10.1161/JAHA.120.020451. Epub 2021 Oct 30. J Am Heart Assoc. 2021. PMID: 34719264 Free PMC article.
Changing cell fate in the wall of pulmonary arteries.
Zhang Y, Michelakis ED. Zhang Y, et al. Sci Transl Med. 2022 May 4;14(643):eabq1908. doi: 10.1126/scitranslmed.abq1908. Epub 2022 May 4. Sci Transl Med. 2022. PMID: 35507673 Review.
p53-Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio-oncology.
Saleme B, Das SK, Zhang Y, Boukouris AE, Lorenzana Carrillo MA, Jovel J, Wagg CS, Lopaschuk GD, Michelakis ED, Sutendra G. Saleme B, et al. Among authors: zhang y. J Am Heart Assoc. 2020 Aug 4;9(15):e017247. doi: 10.1161/JAHA.120.017247. Epub 2020 Jul 29. J Am Heart Assoc. 2020. PMID: 32750288 Free PMC article. No abstract available.
A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.
Boukouris AE, Zhang Y, Saleme B, Kinnaird A, Zhao YY, Liu Y, Zervopoulos SD, Das SK, Mittal RD, Haromy A, Lorenzana-Carrillo MA, Krysler AR, Cromwell CR, Hubbard BP, Sutendra G, Michelakis ED. Boukouris AE, et al. Among authors: zhang y. Cell Rep. 2022 Mar 15;38(11):110511. doi: 10.1016/j.celrep.2022.110511. Cell Rep. 2022. PMID: 35294884 Free article.
Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
Dai XQ, Camunas-Soler J, Briant LJB, Dos Santos T, Spigelman AF, Walker EM, Arrojo E Drigo R, Bautista A, Jones RC, Avrahami D, Lyon J, Nie A, Smith N, Zhang Y, Johnson J, Manning Fox JE, Michelakis ED, Light PE, Kaestner KH, Kim SK, Rorsman P, Stein RW, Quake SR, MacDonald PE. Dai XQ, et al. Among authors: zhang y. Cell Metab. 2022 Feb 1;34(2):256-268.e5. doi: 10.1016/j.cmet.2021.12.021. Cell Metab. 2022. PMID: 35108513 Free PMC article.
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