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A hepatocyte differentiation model reveals two subtypes of liver cancer with different oncofetal properties and therapeutic targets.
Liu M, Yan Q, Sun Y, Nam Y, Hu L, Loong JH, Ouyang Q, Zhang Y, Li HL, Kong FE, Li L, Li Y, Li MM, Cheng W, Jiang LX, Fang S, Yang XD, Mo JQ, Gong YF, Tang YQ, Li Y, Yuan YF, Ma NF, Lin G, Ma S, Wang JG, Guan XY. Liu M, et al. Among authors: zhang y. Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6103-6113. doi: 10.1073/pnas.1912146117. Epub 2020 Mar 2. Proc Natl Acad Sci U S A. 2020. PMID: 32123069 Free PMC article.
PGC7 promotes tumor oncogenic dedifferentiation through remodeling DNA methylation pattern for key developmental transcription factors.
Yan Q, Zhang Y, Fang X, Liu B, Wong TL, Gong L, Liu S, Yu D, Liu M, Jiang L, Wang X, Wei T, Jia Y, Li L, Sun L, Tang Y, Zhou N, Yuan YF, Li Y, Ma S, Guan XY. Yan Q, et al. Among authors: zhang y. Cell Death Differ. 2021 Jun;28(6):1955-1970. doi: 10.1038/s41418-020-00726-3. Epub 2021 Jan 26. Cell Death Differ. 2021. PMID: 33500560 Free PMC article.
Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma.
Gong L, Kwong DL, Dai W, Wu P, Li S, Yan Q, Zhang Y, Zhang B, Fang X, Liu L, Luo M, Liu B, Chow LK, Chen Q, Huang J, Lee VH, Lam KO, Lo AW, Chen Z, Wang Y, Lee AW, Guan XY. Gong L, et al. Among authors: zhang b, zhang y. Nat Commun. 2021 Mar 9;12(1):1540. doi: 10.1038/s41467-021-21795-z. Nat Commun. 2021. PMID: 33750785 Free PMC article.
Elevated expression of RIT1 hyperactivates RAS/MAPK signal and sensitizes hepatocellular carcinoma to combined treatment with sorafenib and AKT inhibitor.
Sun L, Xi S, Zhou Z, Zhang F, Hu P, Cui Y, Wu S, Wang Y, Wu S, Wang Y, Du Y, Zheng J, Yang H, Chen M, Yan Q, Yu D, Shi C, Zhang Y, Xie D, Guan XY, Li Y. Sun L, et al. Among authors: zhang f, zhang y. Oncogene. 2022 Jan;41(5):732-744. doi: 10.1038/s41388-021-02130-8. Epub 2021 Nov 29. Oncogene. 2022. PMID: 34845378
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