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Galeterone and The Next Generation Galeterone Analogs, VNPP414 and VNPP433-3β Exert Potent Therapeutic Effects in Castration-/Drug-Resistant Prostate Cancer Preclinical Models In Vitro and In Vivo.
Kwegyir-Afful AK, Ramalingam S, Ramamurthy VP, Purushottamachar P, Murigi FN, Vasaitis TS, Huang W, Kane MA, Zhang Y, Ambulos N, Tiwari S, Srivastava P, Nnane IP, Hussain A, Qiu Y, Weber DJ, Njar VCO. Kwegyir-Afful AK, et al. Among authors: zhang y. Cancers (Basel). 2019 Oct 24;11(11):1637. doi: 10.3390/cancers11111637. Cancers (Basel). 2019. PMID: 31653008 Free PMC article.
Pre-Clinical Activity of Amino-Alcohol Dimeric Naphthoquinones as Potential Therapeutics for Acute Myeloid Leukemia.
Ferraris D, Lapidus R, Truong P, Bollino D, Carter-Cooper B, Lee M, Chang E, LaRossa-Garcia M, Dash S, Gartenhaus R, Choi EY, Kipe O, Lam V, Mason K, Palmer R, Williams E, Ambulos N, Kamangar F, Zhang Y, Kapadia B, Jing Y, Emadi A. Ferraris D, et al. Among authors: zhang y. Anticancer Agents Med Chem. 2022;22(2):239-253. doi: 10.2174/1871520621666210602131558. Anticancer Agents Med Chem. 2022. PMID: 34080968
Transcriptome profiling reveals that VNPP433-3β, the lead next-generation galeterone analog inhibits prostate cancer stem cells by downregulating epithelial-mesenchymal transition and stem cell markers.
Thomas E, Thankan RS, Purushottamachar P, Huang W, Kane MA, Zhang Y, Ambulos N, Weber DJ, Njar VCO. Thomas E, et al. Among authors: zhang y. Mol Carcinog. 2022 Jul;61(7):643-654. doi: 10.1002/mc.23406. Epub 2022 May 5. Mol Carcinog. 2022. PMID: 35512605 Free PMC article.
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