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NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.
Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. Zhou H, et al. Among authors: zhang hp, zhang xk. Cancer Cell. 2010 Jun 15;17(6):560-73. doi: 10.1016/j.ccr.2010.04.023. Cancer Cell. 2010. PMID: 20541701 Free PMC article.
Sulindac-derived RXRα modulators inhibit cancer cell growth by binding to a novel site.
Chen L, Wang ZG, Aleshin AE, Chen F, Chen J, Jiang F, Alitongbieke G, Zeng Z, Ma Y, Huang M, Zhou H, Cadwell G, Zheng JF, Huang PQ, Liddington RC, Zhang XK, Su Y. Chen L, et al. Among authors: zhang xk. Chem Biol. 2014 May 22;21(5):596-607. doi: 10.1016/j.chembiol.2014.02.017. Epub 2014 Apr 3. Chem Biol. 2014. PMID: 24704507 Free PMC article.
Nitrostyrene Derivatives Act as RXRα Ligands to Inhibit TNFα Activation of NF-κB.
Zeng Z, Sun Z, Huang M, Zhang W, Liu J, Chen L, Chen F, Zhou Y, Lin J, Huang F, Xu L, Zhuang Z, Guo S, Alitongbieke G, Xie G, Xu Y, Lin B, Cao X, Su Y, Zhang XK, Zhou H. Zeng Z, et al. Among authors: zhang w, zhang xk. Cancer Res. 2015 May 15;75(10):2049-60. doi: 10.1158/0008-5472.CAN-14-2435. Epub 2015 Mar 20. Cancer Res. 2015. PMID: 25795708 Free PMC article.
NSC-640358 acts as RXRα ligand to promote TNFα-mediated apoptosis of cancer cell.
Chen F, Chen J, Lin J, Cheltsov AV, Xu L, Chen Y, Zeng Z, Chen L, Huang M, Hu M, Ye X, Zhou Y, Wang G, Su Y, Zhang L, Zhou F, Zhang XK, Zhou H. Chen F, et al. Among authors: zhang l, zhang xk. Protein Cell. 2015 Sep;6(9):654-666. doi: 10.1007/s13238-015-0178-9. Epub 2015 Jul 9. Protein Cell. 2015. PMID: 26156677 Free PMC article.
Targeting truncated RXRα for cancer therapy.
Zhang X, Zhou H, Su Y. Zhang X, et al. Acta Biochim Biophys Sin (Shanghai). 2016 Jan;48(1):49-59. doi: 10.1093/abbs/gmv104. Epub 2015 Oct 21. Acta Biochim Biophys Sin (Shanghai). 2016. PMID: 26494413 Free PMC article. Review.
417 results