Zhang X - Search Results

1

Glucose-induced CRL4^COP1-p53 axis amplifies glycometabolism to drive tumorigenesis.

Su Y, Luo Y, Zhang P, Lin H, Pu W, Zhang H, Wang H, Hao Y, Xiao Y, Zhang X, Wei X, Nie S, Zhang K, Fu Q, Chen H, Huang N, Ren Y, Wu M, Chow BKC, Chen X, Jin W, Wang F, Zhao L, Rao F. Su Y, et al. Among authors: zhang p, zhang k, zhang h, zhang x. Mol Cell. 2023 Jul 6;83(13):2316-2331.e7. doi: 10.1016/j.molcel.2023.06.010. Epub 2023 Jun 29. Mol Cell. 2023. PMID: 37390815

2

Are Inositol Polyphosphates the Missing Link in Dynamic Cullin RING Ligase Regulation by the COP9 Signalosome?

Zhang X, Rao F. Zhang X, et al. Biomolecules. 2019 Aug 7;9(8):349. doi: 10.3390/biom9080349. Biomolecules. 2019. PMID: 31394817 Free PMC article. Review.

3

Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.

Lin H, Zhang X, Liu L, Fu Q, Zang C, Ding Y, Su Y, Xu Z, He S, Yang X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T, Rao F. Lin H, et al. Among authors: zhang x. Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4117-4124. doi: 10.1073/pnas.1911998117. Epub 2020 Feb 11. Proc Natl Acad Sci U S A. 2020. PMID: 32047038 Free PMC article.

4

Suramin and NF449 are IP5K inhibitors that disrupt inositol hexakisphosphate-mediated regulation of cullin-RING ligase and sensitize cancer cells to MLN4924/pevonedistat.

Zhang X, Shi S, Su Y, Yang X, He S, Yang X, Wu J, Zhang J, Rao F. Zhang X, et al. Among authors: zhang j. J Biol Chem. 2020 Jul 24;295(30):10281-10292. doi: 10.1074/jbc.RA120.014375. Epub 2020 Jun 3. J Biol Chem. 2020. PMID: 32493769 Free PMC article.

5

IP₆-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion.

Lin H, Yan Y, Luo Y, So WY, Wei X, Zhang X, Yang X, Zhang J, Su Y, Yang X, Zhang B, Zhang K, Jiang N, Chow BKC, Han W, Wang F, Rao F. Lin H, et al. Among authors: zhang b, zhang j, zhang k, zhang x. Nat Commun. 2021 Apr 28;12(1):2461. doi: 10.1038/s41467-021-22941-3. Nat Commun. 2021. PMID: 33911083 Free PMC article.

6

5-IP₇ is a GPCR messenger mediating neural control of synaptotagmin-dependent insulin exocytosis and glucose homeostasis.

Zhang X, Li N, Zhang J, Zhang Y, Yang X, Luo Y, Zhang B, Xu Z, Zhu Z, Yang X, Yan Y, Lin B, Wang S, Chen D, Ye C, Ding Y, Lou M, Wu Q, Hou Z, Zhang K, Liang Z, Wei A, Wang B, Wang C, Jiang N, Zhang W, Xiao G, Ma C, Ren Y, Qi X, Han W, Wang C, Rao F. Zhang X, et al. Among authors: zhang b, zhang w, zhang j, zhang k, zhang y. Nat Metab. 2021 Oct;3(10):1400-1414. doi: 10.1038/s42255-021-00468-7. Epub 2021 Oct 18. Nat Metab. 2021. PMID: 34663975

7

An autophagy-inducing stapled peptide induces mitochondria dysfunction and triggers autotic cell death in triple-negative breast cancer.

Zhang X, Shan G, Li N, Chen J, Ji C, Li X, Jiang L, Lee TKW, Keng VW, Zhao Y. Zhang X, et al. Cell Death Discov. 2023 Aug 19;9(1):303. doi: 10.1038/s41420-023-01600-0. Cell Death Discov. 2023. PMID: 37598181 Free PMC article.

8

Perturbation of Autophagy by a Beclin 1-Targeting Stapled Peptide Induces Mitochondria Stress and Inhibits Proliferation of Pancreatic Cancer Cells.

Li N, Zhang X, Chen J, Gao S, Wang L, Zhao Y. Li N, et al. Among authors: zhang x. Cancers (Basel). 2023 Feb 2;15(3):953. doi: 10.3390/cancers15030953. Cancers (Basel). 2023. PMID: 36765914 Free PMC article.

9

Optimization of Beclin 1-Targeting Stapled Peptides by Staple Scanning Leads to Enhanced Antiproliferative Potency in Cancer Cells.

Yang Q, Qiu X, Zhang X, Yu Y, Li N, Wei X, Feng G, Li Y, Zhao Y, Wang R. Yang Q, et al. Among authors: zhang x. J Med Chem. 2021 Sep 23;64(18):13475-13486. doi: 10.1021/acs.jmedchem.1c00870. Epub 2021 Sep 10. J Med Chem. 2021. PMID: 34506131

10

A Beclin 1-targeting stapled peptide synergizes with erlotinib to potently inhibit proliferation of non-small-cell lung cancer cells.

Chen J, Zhang X, Gao S, Li N, Keng V, Zhao Y. Chen J, et al. Among authors: zhang x. Biochem Biophys Res Commun. 2022 Dec 25;636(Pt 1):125-131. doi: 10.1016/j.bbrc.2022.10.053. Epub 2022 Oct 20. Biochem Biophys Res Commun. 2022. PMID: 36332474 Free article.

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