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Gelatin promotes cell aggregation and pro-inflammatory cytokine production in PMA-stimulated U937 cells by augmenting endocytosis-autophagy pathway.
Zhao YL, Lu ZY, Zhang X, Liu WW, Yao GD, Liu XL, Liu W, Wu QJ, Hayashi T, Yamato M, Fujisaki H, Hattori S, Atsuzawa Y, Tashiro SI, Onodera S, Ikejima T. Zhao YL, et al. Among authors: zhang x. Int J Biochem Cell Biol. 2018 Feb;95:132-142. doi: 10.1016/j.biocel.2018.01.002. Epub 2018 Jan 4. Int J Biochem Cell Biol. 2018. PMID: 29307663
Phorbol ester (PMA)-treated U937 cells cultured on type I collagen-coated dish express a lower production of pro-inflammatory cytokines through lowered ROS levels in parallel with cell aggregate formation.
Zhao YL, Liu WW, Liu W, Lu ZY, Xuan DH, Zhang X, Liu XL, Hayashi T, Yamato M, Ogura T, Fujisaki H, Hattori S, Tashiro SI, Onodera S, Ikejima T. Zhao YL, et al. Among authors: zhang x. Int Immunopharmacol. 2018 Feb;55:158-164. doi: 10.1016/j.intimp.2017.12.013. Epub 2017 Dec 22. Int Immunopharmacol. 2018. PMID: 29253822
Reactive oxygen species are responsible for the cell aggregation and production of pro-inflammatory mediators in phorbol ester (PMA)-treated U937 cells on gelatin-coated dishes through upregulation of autophagy.
Zhao YL, Zhang X, Liu WW, Yang YT, Gao ZK, Liu XL, Liu W, Hayashi T, Yamato M, Fujisaki H, Hattori S, Mizuno K, Atsuzawa Y, Tashiro SI, Onodera S, Ikejima T. Zhao YL, et al. Among authors: zhang x. Connect Tissue Res. 2019 Jul;60(4):323-334. doi: 10.1080/03008207.2018.1530770. Epub 2018 Dec 25. Connect Tissue Res. 2019. PMID: 30277081
MUC16: clinical targets with great potential.
Zhang XY, Hong LL, Ling ZQ. Zhang XY, et al. Clin Exp Med. 2024 May 17;24(1):101. doi: 10.1007/s10238-024-01365-5. Clin Exp Med. 2024. PMID: 38758220 Review.
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