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Targeting Nur77 translocation.
Zhang XK. Zhang XK. Expert Opin Ther Targets. 2007 Jan;11(1):69-79. doi: 10.1517/14728222.11.1.69. Expert Opin Ther Targets. 2007. PMID: 17150035 Review.
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Dawson MI, Xia Z, Liu G, Ye M, Fontana JA, Farhana L, Patel BB, Arumugarajah S, Bhuiyan M, Zhang XK, Han YH, Stallcup WB, Fukushi J, Mustelin T, Tautz L, Su Y, Harris DL, Waleh N, Hobbs PD, Jong L, Chao WR, Schiff LJ, Sani BP. Dawson MI, et al. J Med Chem. 2007 May 31;50(11):2622-39. doi: 10.1021/jm0613323. Epub 2007 May 10. J Med Chem. 2007. PMID: 17489579 Free PMC article.
Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators.
Jiang MM, Dai Y, Gao H, Zhang X, Wang GH, He JY, Hu QY, Zeng JZ, Zhang XK, Yao XS. Jiang MM, et al. Among authors: zhang xk, zhang x. Chem Pharm Bull (Tokyo). 2008 Jul;56(7):1005-8. doi: 10.1248/cpb.56.1005. Chem Pharm Bull (Tokyo). 2008. PMID: 18591820 Free article.
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, Hobbs PD, Jong L, Waleh N, Chao WR, Feng GS, Pang Y, Su Y. Dawson MI, et al. J Med Chem. 2008 Sep 25;51(18):5650-62. doi: 10.1021/jm800456k. Epub 2008 Aug 30. J Med Chem. 2008. PMID: 18759424 Free PMC article.
A short Nur77-derived peptide converts Bcl-2 from a protector to a killer.
Kolluri SK, Zhu X, Zhou X, Lin B, Chen Y, Sun K, Tian X, Town J, Cao X, Lin F, Zhai D, Kitada S, Luciano F, O'Donnell E, Cao Y, He F, Lin J, Reed JC, Satterthwait AC, Zhang XK. Kolluri SK, et al. Among authors: zhang xk. Cancer Cell. 2008 Oct 7;14(4):285-98. doi: 10.1016/j.ccr.2008.09.002. Cancer Cell. 2008. PMID: 18835031 Free PMC article.
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