Zhang T - Search Results

1

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors.

Gao S, Song L, Claff T, Woodson M, Sylvester K, Jing L, Weiße RH, Cheng Y, Sträter N, Schäkel L, Gütschow M, Ye B, Yang M, Zhang T, Kang D, Toth K, Tavis J, Tollefson AE, Müller CE, Zhan P, Liu X. Gao S, et al. Among authors: zhang t. J Med Chem. 2022 Dec 22;65(24):16902-16917. doi: 10.1021/acs.jmedchem.2c01716. Epub 2022 Dec 7. J Med Chem. 2022. PMID: 36475694

2

Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening.

Yang B, Lamb ML, Zhang T, Hennessy EJ, Grewal G, Sha L, Zambrowski M, Block MH, Dowling JE, Su N, Wu J, Deegan T, Mikule K, Wang W, Kaspera R, Chuaqui C, Chen H. Yang B, et al. Among authors: zhang t. J Med Chem. 2014 Dec 11;57(23):9958-70. doi: 10.1021/jm501179r. Epub 2014 Dec 2. J Med Chem. 2014. PMID: 25458601

3

Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs.

Sun Y, Zhou Z, Feng D, Jing L, Zhao F, Wang Z, Zhang T, Lin H, Song H, De Clercq E, Pannecouque C, Zhan P, Liu X, Kang D. Sun Y, et al. Among authors: zhang t. J Med Chem. 2022 Dec 8;65(23):15608-15626. doi: 10.1021/acs.jmedchem.2c00576. Epub 2022 Nov 21. J Med Chem. 2022. PMID: 36411036

4

5-Cyano substituted diarylpyridines as potent HIV-1 NNRTIs: Rational design, synthesis, and activity evaluation.

Song H, Xia Y, Zhang T, Dun C, Meng B, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Song H, et al. Among authors: zhang t. Eur J Med Chem. 2023 Nov 5;259:115686. doi: 10.1016/j.ejmech.2023.115686. Epub 2023 Jul 29. Eur J Med Chem. 2023. PMID: 37536208

5

Discovery of benzamide-based PI3K/HDAC dual inhibitors with marked pro-apoptosis activity in lymphoma cells.

Deng J, Hou B, Hou X, Chen Y, Zhang T, Chen H, Wang Y, Li X. Deng J, et al. Among authors: zhang t. Eur J Med Chem. 2023 Dec 15;262:115915. doi: 10.1016/j.ejmech.2023.115915. Epub 2023 Nov 3. Eur J Med Chem. 2023. PMID: 37948955

6

In situ click chemistry-based discovery of 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs by exploiting the tolerant region I in binding pocket.

Sun Y, Feng D, Zhou Z, Zhang T, De Clercq E, Pannecouque C, Kang D, Zhan P, Liu X. Sun Y, et al. Among authors: zhang t. Bioorg Med Chem. 2023 Dec 15;96:117484. doi: 10.1016/j.bmc.2023.117484. Epub 2023 Sep 23. Bioorg Med Chem. 2023. PMID: 37976805

7

Selective Antitumor Effect and Lower Toxicity of Mitochondrion-Targeting Derivatization of Triptolide.

Xing W, Liu G, Zhang Y, Zhang T, Lou H, Fan P. Xing W, et al. Among authors: zhang t, zhang y. J Med Chem. 2024 Jan 25;67(2):1093-1114. doi: 10.1021/acs.jmedchem.3c01508. Epub 2024 Jan 3. J Med Chem. 2024. PMID: 38169372

8

Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases.

Dakin LA, Block MH, Chen H, Code E, Dowling JE, Feng X, Ferguson AD, Green I, Hird AW, Howard T, Keeton EK, Lamb ML, Lyne PD, Pollard H, Read J, Wu AJ, Zhang T, Zheng X. Dakin LA, et al. Among authors: zhang t. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4599-604. doi: 10.1016/j.bmcl.2012.05.098. Epub 2012 Jun 6. Bioorg Med Chem Lett. 2012. PMID: 22727640

9

Design and synthesis of fascaplysin derivatives as inhibitors of FtsZ with potent antibacterial activity and mechanistic study.

Qiu H, Zhao X, Jiang Y, Liang W, Wang W, Jiang X, Jiang M, Wang X, Cui W, Li Y, Tang K, Zhang T, Zhao L, Liang H. Qiu H, et al. Among authors: zhang t. Eur J Med Chem. 2023 Jun 5;254:115348. doi: 10.1016/j.ejmech.2023.115348. Epub 2023 Apr 11. Eur J Med Chem. 2023. PMID: 37060755

10

Mitochondrial targeting derivatives of honokiol enhanced selective antitumor activity in NCI-H446 cells and decreased in vivo toxicity in Caenorhabditis elegans.

Miao H, Cui W, Zhang T, Zhang Y, Zhang J, Lou H, Fan P. Miao H, et al. Among authors: zhang t, zhang j, zhang y. Eur J Med Chem. 2024 Jan 15;264:115996. doi: 10.1016/j.ejmech.2023.115996. Epub 2023 Dec 3. Eur J Med Chem. 2024. PMID: 38086195

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

35,207 results

Search Page