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mTORC1 activity is supported by spatial association with focal adhesions.
Rabanal-Ruiz Y, Byron A, Wirth A, Madsen R, Sedlackova L, Hewitt G, Nelson G, Stingele J, Wills JC, Zhang T, Zeug A, Fässler R, Vanhaesebroeck B, Maddocks ODK, Ponimaskin E, Carroll B, Korolchuk VI. Rabanal-Ruiz Y, et al. Among authors: zhang t. J Cell Biol. 2021 May 3;220(5):e202004010. doi: 10.1083/jcb.202004010. J Cell Biol. 2021. PMID: 33635313 Free PMC article.
Modulating the therapeutic response of tumours to dietary serine and glycine starvation.
Maddocks ODK, Athineos D, Cheung EC, Lee P, Zhang T, van den Broek NJF, Mackay GM, Labuschagne CF, Gay D, Kruiswijk F, Blagih J, Vincent DF, Campbell KJ, Ceteci F, Sansom OJ, Blyth K, Vousden KH. Maddocks ODK, et al. Among authors: zhang t. Nature. 2017 Apr 19;544(7650):372-376. doi: 10.1038/nature22056. Nature. 2017. PMID: 28425994 Free article.
Persistent mTORC1 signaling in cell senescence results from defects in amino acid and growth factor sensing.
Carroll B, Nelson G, Rabanal-Ruiz Y, Kucheryavenko O, Dunhill-Turner NA, Chesterman CC, Zahari Q, Zhang T, Conduit SE, Mitchell CA, Maddocks ODK, Lovat P, von Zglinicki T, Korolchuk VI. Carroll B, et al. Among authors: zhang t. J Cell Biol. 2017 Jul 3;216(7):1949-1957. doi: 10.1083/jcb.201610113. Epub 2017 May 31. J Cell Biol. 2017. PMID: 28566325 Free PMC article.
Assessment of Tumor Redox Status through (S)-4-(3-[18F]fluoropropyl)-L-Glutamic Acid PET Imaging of System xc - Activity.
McCormick PN, Greenwood HE, Glaser M, Maddocks ODK, Gendron T, Sander K, Gowrishankar G, Hoehne A, Zhang T, Shuhendler AJ, Lewis DY, Berndt M, Koglin N, Lythgoe MF, Gambhir SS, Årstad E, Witney TH. McCormick PN, et al. Among authors: zhang t. Cancer Res. 2019 Feb 15;79(4):853-863. doi: 10.1158/0008-5472.CAN-18-2634. Epub 2018 Nov 6. Cancer Res. 2019. PMID: 30401715 Free PMC article.
Metabolic tracing reveals novel adaptations to skeletal muscle cell energy production pathways in response to NAD + depletion.
Oakey LA, Fletcher RS, Elhassan YS, Cartwright DM, Doig CL, Garten A, Thakker A, Maddocks ODK, Zhang T, Tennant DA, Ludwig C, Lavery GG. Oakey LA, et al. Among authors: zhang t. Wellcome Open Res. 2019 Sep 17;3:147. doi: 10.12688/wellcomeopenres.14898.2. eCollection 2018. Wellcome Open Res. 2019. PMID: 30607371 Free PMC article.
Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography.
Greenwood HE, McCormick PN, Gendron T, Glaser M, Pereira R, Maddocks ODK, Sander K, Zhang T, Koglin N, Lythgoe MF, Årstad E, Hochhauser D, Witney TH. Greenwood HE, et al. Among authors: zhang t. Clin Cancer Res. 2019 Apr 15;25(8):2471-2482. doi: 10.1158/1078-0432.CCR-18-3423. Epub 2019 Jan 16. Clin Cancer Res. 2019. PMID: 30651275 Free PMC article.
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