Zhang S - Search Results

1

Small-Molecule Modulators of Toll-like Receptors.

Wang Y, Zhang S, Li H, Wang H, Zhang T, Hutchinson MR, Yin H, Wang X. Wang Y, et al. Among authors: zhang s, zhang t. Acc Chem Res. 2020 May 19;53(5):1046-1055. doi: 10.1021/acs.accounts.9b00631. Epub 2020 Apr 1. Acc Chem Res. 2020. PMID: 32233400 Review.

2

Discovery of small-molecule inhibitors of the TLR1/TLR2 complex.

Cheng K, Wang X, Zhang S, Yin H. Cheng K, et al. Among authors: zhang s. Angew Chem Int Ed Engl. 2012 Dec 3;51(49):12246-9. doi: 10.1002/anie.201204910. Epub 2012 Sep 11. Angew Chem Int Ed Engl. 2012. PMID: 22969053 Free PMC article.

3

Selection, synthesis, and anti-inflammatory evaluation of the arylidene malonate derivatives as TLR4 signaling inhibitors.

Zhang S, Cheng K, Wang X, Yin H. Zhang S, et al. Bioorg Med Chem. 2012 Oct 15;20(20):6073-9. doi: 10.1016/j.bmc.2012.08.022. Epub 2012 Aug 25. Bioorg Med Chem. 2012. PMID: 22985959 Free PMC article.

4

A ratiometric two-photon fluorescent probe for hydrazine and its applications.

Yu S, Wang S, Yu H, Feng Y, Zhang S, Zhu M, Yin H, Meng X. Yu S, et al. Among authors: zhang s. Sens Actuators B Chem. 2015 Dec 1;220:1338-1345. doi: 10.1016/j.snb.2015.07.051. Sens Actuators B Chem. 2015. PMID: 26500394 Free PMC article.

5

Small Molecule and Peptide Recognition of Protein Transmembrane Domains.

Zeng X, Wu P, Yao C, Liang J, Zhang S, Yin H. Zeng X, et al. Among authors: zhang s. Biochemistry. 2017 Apr 18;56(15):2076-2085. doi: 10.1021/acs.biochem.6b00909. Epub 2017 Apr 3. Biochemistry. 2017. PMID: 28353343

6

Small-molecule inhibition of TLR8 through stabilization of its resting state.

Zhang S, Hu Z, Tanji H, Jiang S, Das N, Li J, Sakaniwa K, Jin J, Bian Y, Ohto U, Shimizu T, Yin H. Zhang S, et al. Nat Chem Biol. 2018 Jan;14(1):58-64. doi: 10.1038/nchembio.2518. Epub 2017 Nov 20. Nat Chem Biol. 2018. PMID: 29155428 Free PMC article.

7

Small-Molecule TLR8 Antagonists via Structure-Based Rational Design.

Hu Z, Tanji H, Jiang S, Zhang S, Koo K, Chan J, Sakaniwa K, Ohto U, Candia A, Shimizu T, Yin H. Hu Z, et al. Among authors: zhang s. Cell Chem Biol. 2018 Oct 18;25(10):1286-1291.e3. doi: 10.1016/j.chembiol.2018.07.004. Epub 2018 Aug 9. Cell Chem Biol. 2018. PMID: 30100350 Free PMC article.

8

Discovery of Novel Small Molecule Dual Inhibitors Targeting Toll-Like Receptors 7 and 8.

Padilla-Salinas R, Anderson R, Sakaniwa K, Zhang S, Nordeen P, Lu C, Shimizu T, Yin H. Padilla-Salinas R, et al. Among authors: zhang s. J Med Chem. 2019 Nov 27;62(22):10221-10244. doi: 10.1021/acs.jmedchem.9b01201. Epub 2019 Nov 18. J Med Chem. 2019. PMID: 31687820

9

Discovery of Small-Molecule Cyclic GMP-AMP Synthase Inhibitors.

Padilla-Salinas R, Sun L, Anderson R, Yang X, Zhang S, Chen ZJ, Yin H. Padilla-Salinas R, et al. Among authors: zhang s. J Org Chem. 2020 Feb 7;85(3):1579-1600. doi: 10.1021/acs.joc.9b02666. Epub 2020 Jan 3. J Org Chem. 2020. PMID: 31829590

10

Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface.

Jiang S, Tanji H, Yin K, Zhang S, Sakaniwa K, Huang J, Yang Y, Li J, Ohto U, Shimizu T, Yin H. Jiang S, et al. Among authors: zhang s. J Med Chem. 2020 Apr 23;63(8):4117-4132. doi: 10.1021/acs.jmedchem.9b02128. Epub 2020 Apr 13. J Med Chem. 2020. PMID: 32233366

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