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SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis.
Song C, Liu D, Liu S, Li D, Horecny I, Zhang X, Li P, Chen L, Miller M, Chowdhury R, Issa M, Shen R, Yan Y, Zhang F, Zhang L, Zhang L, Bai C, Feng J, Zhuang L, Zhang R, Li J, Wilkinson H, Liu J, Tao W. Song C, et al. Among authors: zhang l, zhang r, zhang f, zhang x. Sci Rep. 2022 May 20;12(1):8579. doi: 10.1038/s41598-022-12449-1. Sci Rep. 2022. PMID: 35595822 Free PMC article.
A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer.
Liu S, Li D, Liu J, Wang H, Horecny I, Shen R, Zhang R, Wu H, Hu Q, Zhao P, Zhang F, Yan Y, Feng J, Zhuang L, Li J, Zhang L, Tao W. Liu S, et al. Among authors: zhang l, zhang r, zhang f. Onco Targets Ther. 2021 Aug 24;14:4561-4574. doi: 10.2147/OTT.S326178. eCollection 2021. Onco Targets Ther. 2021. PMID: 34466002 Free PMC article.
Discovery of 2-(Ortho-Substituted Benzyl)-Indole Derivatives as Potent and Orally Bioavailable RORγ Agonists with Antitumor Activity.
Lu B, Liu D, Gui B, Gou J, Dong H, Hu Q, Feng J, Mao Y, Shen X, Wang S, Zhang C, Shen R, Yan Y, Chen L, Wang H, Li D, Zhang J, Zhang M, Zhang R, Bai C, He F, Tao W, Liu S. Lu B, et al. Among authors: zhang m, zhang r, zhang c, zhang j. J Med Chem. 2021 Oct 28;64(20):14983-14996. doi: 10.1021/acs.jmedchem.1c00828. Epub 2021 Oct 13. J Med Chem. 2021. PMID: 34643383
Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.
Zhao P, Zhuang L, Wang X, Huang S, Wu H, Zhou Y, Yan Y, Zhang F, Shen R, Li J, Liu S, Zhang R, Dong P, Mao Y, Fan Y, He C, Sun J, Zhang L, Hu Q, Wan H, Feng J, Bai C, He F, Tao W. Zhao P, et al. Among authors: zhang l, zhang r, zhang f. Eur J Med Chem. 2022 Jan 15;228:114040. doi: 10.1016/j.ejmech.2021.114040. Epub 2021 Dec 7. Eur J Med Chem. 2022. PMID: 34906761
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