Zhang R - Search Results

1

Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists.

Song F, Xu G, Gaul MD, Zhao B, Lu T, Zhang R, DesJarlais RL, DiLoreto K, Huebert N, Shook B, Rentzeperis D, Santulli R, Eckardt A, Demarest K. Song F, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2019 Aug 1;29(15):1974-1980. doi: 10.1016/j.bmcl.2019.05.036. Epub 2019 May 18. Bioorg Med Chem Lett. 2019. PMID: 31138472

2

4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.

Yang SM, Tang Y, Zhang R, Lu H, Kuo GH, Gaul MD, Li Y, Ho G, Conway JG, Liang Y, Lenhard JM, Demarest KT, Murray WV. Yang SM, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6773-6. doi: 10.1016/j.bmcl.2013.09.096. Epub 2013 Oct 9. Bioorg Med Chem Lett. 2013. PMID: 24153205

3

Discovery of para-alkylthiophenoxyacetic acids as a novel series of potent and selective PPARdelta agonists.

Zhang R, Wang A, DeAngelis A, Pelton P, Xu J, Zhu P, Zhou L, Demarest K, Murray WV, Kuo GH. Zhang R, et al. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3855-9. doi: 10.1016/j.bmcl.2007.05.007. Epub 2007 May 10. Bioorg Med Chem Lett. 2007. PMID: 17524639

4

Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.

Zhang R, Deangelis A, Wang A, Sieber-McMaster E, Li X, Russell R, Pelton P, Xu J, Zhu P, Zhou L, Demarest K, Murray WV, Kuo GH. Zhang R, et al. Bioorg Med Chem Lett. 2009 Feb 15;19(4):1101-4. doi: 10.1016/j.bmcl.2008.12.113. Epub 2009 Jan 8. Bioorg Med Chem Lett. 2009. PMID: 19168353

5

Design, synthesis and preclinical evaluation of bio-conjugated amylinomimetic peptides as long-acting amylin receptor agonists.

Patch RJ, Zhang R, Edavettal S, Macielag MJ, Eckardt AJ, Li J, Rives ML, Edwards W, Hinke SA, Qiu X, Jian W, Libiger O, Zheng S, Jeyaseelan J, Liang Y, Rangwala SM, Leonard JN, Hornby P. Patch RJ, et al. Among authors: zhang r. Eur J Med Chem. 2022 Jun 5;236:114330. doi: 10.1016/j.ejmech.2022.114330. Epub 2022 Apr 4. Eur J Med Chem. 2022. PMID: 35436670

6

Efforts towards the optimization of a bi-aryl class of potent IRAK4 inhibitors.

Hanisak J, Seganish WM, McElroy WT, Tang H, Zhang R, Tsui HC, Fischmann T, Tulshian D, Tata J, Sondey C, Devito K, Fossetta J, Garlisi CG, Lundell D, Niu X. Hanisak J, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4250-5. doi: 10.1016/j.bmcl.2016.07.048. Epub 2016 Jul 22. Bioorg Med Chem Lett. 2016. PMID: 27476420

7

Identification and structure-activity relationships of ortho-biphenyl carboxamides as potent Smoothened antagonists inhibiting the Hedgehog signaling pathway.

Peukert S, Jain RK, Geisser A, Sun Y, Zhang R, Bourret A, Carlson A, Dasilva J, Ramamurthy A, Kelleher JF. Peukert S, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2009 Jan 15;19(2):328-31. doi: 10.1016/j.bmcl.2008.11.096. Epub 2008 Dec 3. Bioorg Med Chem Lett. 2009. PMID: 19091559

8

1-amino-4-benzylphthalazines as orally bioavailable smoothened antagonists with antitumor activity.

Miller-Moslin K, Peukert S, Jain RK, McEwan MA, Karki R, Llamas L, Yusuff N, He F, Li Y, Sun Y, Dai M, Perez L, Michael W, Sheng T, Lei H, Zhang R, Williams J, Bourret A, Ramamurthy A, Yuan J, Guo R, Matsumoto M, Vattay A, Maniara W, Amaral A, Dorsch M, Kelleher JF 3rd. Miller-Moslin K, et al. Among authors: zhang r. J Med Chem. 2009 Jul 9;52(13):3954-68. doi: 10.1021/jm900309j. J Med Chem. 2009. PMID: 19469545

9

Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation.

Xu A, He F, Zhang X, Li X, Ran Y, Wei C, James Chou C, Zhang R, Wu J. Xu A, et al. Among authors: zhang r, zhang x. Bioorg Chem. 2020 May;98:103721. doi: 10.1016/j.bioorg.2020.103721. Epub 2020 Mar 3. Bioorg Chem. 2020. PMID: 32193030

10

Discovery of novel aminosaccharide-based sulfonamide derivatives as potential carbonic anhydrase II inhibitors.

Wang X, Feng YL, Zhao XY, An R, Cao C, Guo MB, Zhang R, Wang YX, Hou Z, Guo C. Wang X, et al. Among authors: zhang r. Bioorg Med Chem Lett. 2021 Dec 1;53:128420. doi: 10.1016/j.bmcl.2021.128420. Epub 2021 Oct 30. Bioorg Med Chem Lett. 2021. PMID: 34728369

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