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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity.
Lv D, Pal P, Liu X, Jia Y, Thummuri D, Zhang P, Hu W, Pei J, Zhang Q, Zhou S, Khan S, Zhang X, Hua N, Yang Q, Arango S, Zhang W, Nayak D, Olsen SK, Weintraub ST, Hromas R, Konopleva M, Yuan Y, Zheng G, Zhou D. Lv D, et al. Among authors: zhang p, zhang q, zhang w, zhang x. Nat Commun. 2021 Nov 25;12(1):6896. doi: 10.1038/s41467-021-27210-x. Nat Commun. 2021. PMID: 34824248 Free PMC article.
A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity.
Khan S, Zhang X, Lv D, Zhang Q, He Y, Zhang P, Liu X, Thummuri D, Yuan Y, Wiegand JS, Pei J, Zhang W, Sharma A, McCurdy CR, Kuruvilla VM, Baran N, Ferrando AA, Kim YM, Rogojina A, Houghton PJ, Huang G, Hromas R, Konopleva M, Zheng G, Zhou D. Khan S, et al. Among authors: zhang p, zhang q, zhang w, zhang x. Nat Med. 2019 Dec;25(12):1938-1947. doi: 10.1038/s41591-019-0668-z. Epub 2019 Dec 2. Nat Med. 2019. PMID: 31792461 Free PMC article.
Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity.
He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. He Y, et al. Among authors: zhang p, zhang x. Nat Commun. 2020 Apr 24;11(1):1996. doi: 10.1038/s41467-020-15838-0. Nat Commun. 2020. PMID: 32332723 Free PMC article.
Concise Synthesis of (S)-δ-CEHC, a Metabolite of Vitamin E.
Burke M, Pal P, Zhang P, Zhang X, Zheng G. Burke M, et al. Among authors: zhang p, zhang x. ACS Omega. 2021 Feb 2;6(6):4355-4361. doi: 10.1021/acsomega.0c05658. eCollection 2021 Feb 16. ACS Omega. 2021. PMID: 33623846 Free PMC article.
Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells.
Kolb R, De U, Khan S, Luo Y, Kim MC, Yu H, Wu C, Mo J, Zhang X, Zhang P, Zhang X, Borcherding N, Koppel D, Fu YX, Zheng SG, Avram D, Zheng G, Zhou D, Zhang W. Kolb R, et al. Among authors: zhang p, zhang w, zhang x. Nat Commun. 2021 Feb 24;12(1):1281. doi: 10.1038/s41467-021-21573-x. Nat Commun. 2021. PMID: 33627663 Free PMC article.
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