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Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates.
Wang PX, Ji YX, Zhang XJ, Zhao LP, Yan ZZ, Zhang P, Shen LJ, Yang X, Fang J, Tian S, Zhu XY, Gong J, Zhang X, Wei QF, Wang Y, Li J, Wan L, Xie Q, She ZG, Wang Z, Huang Z, Li H. Wang PX, et al. Among authors: zhang p, zhang xj, zhang x. Nat Med. 2017 Apr;23(4):439-449. doi: 10.1038/nm.4290. Epub 2017 Feb 20. Nat Med. 2017. PMID: 28218919
The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis.
Ji YX, Huang Z, Yang X, Wang X, Zhao LP, Wang PX, Zhang XJ, Alves-Bezerra M, Cai L, Zhang P, Lu YX, Bai L, Gao MM, Zhao H, Tian S, Wang Y, Huang ZX, Zhu XY, Zhang Y, Gong J, She ZG, Li F, Cohen DE, Li H. Ji YX, et al. Among authors: zhang p, zhang xj, zhang y. Nat Med. 2018 Feb;24(2):213-223. doi: 10.1038/nm.4461. Epub 2018 Jan 1. Nat Med. 2018. PMID: 29291351
TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease.
Zhao GN, Tian ZW, Tian T, Zhu ZP, Zhao WJ, Tian H, Cheng X, Hu FJ, Hu ML, Tian S, Ding T, Chen S, Ji YX, Zhang P, Zhang XJ, She ZG, Yuan Y, Chen W, Bai L, Li H. Zhao GN, et al. Among authors: zhang p, zhang xj. Cell Metab. 2021 Aug 3;33(8):1640-1654.e8. doi: 10.1016/j.cmet.2021.05.014. Epub 2021 Jun 8. Cell Metab. 2021. PMID: 34107313 Free article.
Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis.
Zhang XJ, She ZG, Wang J, Sun D, Shen LJ, Xiang H, Cheng X, Ji YX, Huang YP, Li PL, Yang X, Cheng Y, Ma JP, Wang HP, Hu Y, Hu F, Tian S, Tian H, Zhang P, Zhao GN, Wang L, Hu ML, Yang Q, Zhu LH, Cai J, Yang J, Zhang X, Ma X, Xu Q, Touyz RM, Liu PP, Loomba R, Wang Y, Li H. Zhang XJ, et al. Among authors: zhang p, zhang x. Sci Transl Med. 2021 Dec 15;13(624):eabg8117. doi: 10.1126/scitranslmed.abg8117. Epub 2021 Dec 15. Sci Transl Med. 2021. PMID: 34910546
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