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FBXO22 degrades nuclear PTEN to promote tumorigenesis.
Ge MK, Zhang N, Xia L, Zhang C, Dong SS, Li ZM, Ji Y, Zheng MH, Sun J, Chen GQ, Shen SM. Ge MK, et al. Among authors: zhang n, zhang c. Nat Commun. 2020 Apr 6;11(1):1720. doi: 10.1038/s41467-020-15578-1. Nat Commun. 2020. PMID: 32249768 Free PMC article.
PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.
Shen SM, Zhang C, Ge MK, Dong SS, Xia L, He P, Zhang N, Ji Y, Yang S, Yu Y, Zheng JK, Yu JX, Xia Q, Chen GQ. Shen SM, et al. Among authors: zhang n, zhang c. Nat Cell Biol. 2019 Nov;21(11):1436-1448. doi: 10.1038/s41556-019-0409-z. Epub 2019 Nov 4. Nat Cell Biol. 2019. PMID: 31685992
The tRNA-GCN2-FBXO22-axis-mediated mTOR ubiquitination senses amino acid insufficiency.
Ge MK, Zhang C, Zhang N, He P, Cai HY, Li S, Wu S, Chu XL, Zhang YX, Ma HM, Xia L, Yang S, Yu JX, Yao SY, Zhou XL, Su B, Chen GQ, Shen SM. Ge MK, et al. Among authors: zhang n, zhang c, zhang yx. Cell Metab. 2023 Dec 5;35(12):2216-2230.e8. doi: 10.1016/j.cmet.2023.10.016. Epub 2023 Nov 17. Cell Metab. 2023. PMID: 37979583
Cytochrome P450 Enzymes and Drug Metabolism in Humans.
Zhao M, Ma J, Li M, Zhang Y, Jiang B, Zhao X, Huai C, Shen L, Zhang N, He L, Qin S. Zhao M, et al. Among authors: zhang n, zhang y. Int J Mol Sci. 2021 Nov 26;22(23):12808. doi: 10.3390/ijms222312808. Int J Mol Sci. 2021. PMID: 34884615 Free PMC article. Review.
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