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Discovery of a first-in-class orally available HBV cccDNA inhibitor.
Wang L, Zhu Q, Zhang JD, Zhang Y, Ni X, Xiang K, Jiang J, Li B, Yu Y, Hu H, Zhang M, Wu W, Zeng J, Yan Z, Dai J, Sun K, Zhang X, Chen D, Feng S, Sach-Peltason L, Young JAT, Gao L. Wang L, et al. Among authors: zhang m, zhang jd, zhang x, zhang y. J Hepatol. 2023 Apr;78(4):742-753. doi: 10.1016/j.jhep.2022.12.014. Epub 2022 Dec 30. J Hepatol. 2023. PMID: 36587899
Discovery of Novel cccDNA Reducers toward the Cure of Hepatitis B Virus Infection.
Chen D, Tan X, Chen W, Liu Y, Li C, Wu J, Zheng J, Shen HC, Zhang M, Wu W, Wang L, Xiong J, Dai J, Sun K, Zhang JD, Xiang K, Li B, Ni X, Zhu Q, Gao L, Wang L, Feng S. Chen D, et al. Among authors: zhang m, zhang jd. J Med Chem. 2022 Aug 25;65(16):10938-10955. doi: 10.1021/acs.jmedchem.1c02215. Epub 2022 Aug 16. J Med Chem. 2022. PMID: 35973101
Discovery of a Novel Respiratory Syncytial Virus Replication Inhibitor.
Wang L, Zhu Q, Xiang K, Zhang Y, Li B, Yu X, Yang G, Liang C, Yun H, Zhang M, Qin N, Gao L. Wang L, et al. Among authors: zhang m, zhang y. Antimicrob Agents Chemother. 2021 May 18;65(6):e02576-20. doi: 10.1128/AAC.02576-20. Print 2021 May 18. Antimicrob Agents Chemother. 2021. PMID: 33782012 Free PMC article.
Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways.
Zhang C, Wu X, Zhang M, Zhu L, Zhao R, Xu D, Lin Z, Liang C, Chen T, Chen L, Ren Y, Zhang J, Qin N, Zhang X. Zhang C, et al. Among authors: zhang m, zhang j, zhang x. PLoS One. 2013 Jun 5;8(6):e65264. doi: 10.1371/journal.pone.0065264. Print 2013. PLoS One. 2013. PMID: 23755206 Free PMC article.
Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.
Tang G, Wong JC, Zhang W, Wang Z, Zhang N, Peng Z, Zhang Z, Rong Y, Li S, Zhang M, Yu L, Feng T, Zhang X, Wu X, Wu JZ, Chen L. Tang G, et al. Among authors: zhang n, zhang m, zhang w, zhang z, zhang x. J Med Chem. 2014 Oct 9;57(19):8026-34. doi: 10.1021/jm5008962. Epub 2014 Sep 30. J Med Chem. 2014. PMID: 25238284
Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy.
Sun Q, Zhou J, Zhang Z, Guo M, Liang J, Zhou F, Long J, Zhang W, Yin F, Cai H, Yang H, Zhang W, Gu Y, Ni L, Sai Y, Cui Y, Zhang M, Hong M, Sun J, Yang Z, Qing W, Su W, Ren Y. Sun Q, et al. Among authors: zhang m, zhang w, zhang z. Cancer Biol Ther. 2014;15(12):1635-45. doi: 10.4161/15384047.2014.964087. Cancer Biol Ther. 2014. PMID: 25482937 Free PMC article.
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