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Low-dose metformin targets the lysosomal AMPK pathway through PEN2.
Ma T, Tian X, Zhang B, Li M, Wang Y, Yang C, Wu J, Wei X, Qu Q, Yu Y, Long S, Feng JW, Li C, Zhang C, Xie C, Wu Y, Xu Z, Chen J, Yu Y, Huang X, He Y, Yao L, Zhang L, Zhu M, Wang W, Wang ZC, Zhang M, Bao Y, Jia W, Lin SY, Ye Z, Piao HL, Deng X, Zhang CS, Lin SC. Ma T, et al. Among authors: zhang l, zhang m, zhang b, zhang c, zhang cs. Nature. 2022 Mar;603(7899):159-165. doi: 10.1038/s41586-022-04431-8. Epub 2022 Feb 23. Nature. 2022. PMID: 35197629 Free PMC article.
Beta-arrestin-1 protein represses diet-induced obesity.
Zhuang LN, Hu WX, Zhang ML, Xin SM, Jia WP, Zhao J, Pei G. Zhuang LN, et al. J Biol Chem. 2011 Aug 12;286(32):28396-402. doi: 10.1074/jbc.M111.223206. Epub 2011 May 4. J Biol Chem. 2011. PMID: 21543334 Free PMC article.
Loss of β-arrestin2 mediates pancreatic-islet dysfunction in mice.
Zhang M, Zhu Y, Mu K, Li L, Lu J, Zhao J, Huang X, Wang C, Jia W. Zhang M, et al. Biochem Biophys Res Commun. 2013 Jun 7;435(3):345-9. doi: 10.1016/j.bbrc.2013.04.079. Epub 2013 May 6. Biochem Biophys Res Commun. 2013. PMID: 23660189
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