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Unraveling pleiotropic effects of rifampicin by using physiologically based pharmacokinetic modeling: Assessing the induction magnitude of P-glycoprotein-cytochrome P450 3A4 dual substrates.
Pan X, Yamazaki S, Neuhoff S, Zhang M, Pilla Reddy V. Pan X, et al. Among authors: zhang m. CPT Pharmacometrics Syst Pharmacol. 2021 Dec;10(12):1485-1496. doi: 10.1002/psp4.12717. Epub 2021 Nov 2. CPT Pharmacometrics Syst Pharmacol. 2021. PMID: 34729944 Free PMC article.
Understanding Interindividual Variability in the Drug Interaction of a Highly Extracted CYP1A2 Substrate Tizanidine: Application of a Permeability-Limited Multicompartment Liver Model in a Population Based Physiologically Based Pharmacokinetic Framework.
Zhang M, Fisher C, Gardner I, Pan X, Kilford P, Bois FY, Jamei M. Zhang M, et al. Drug Metab Dispos. 2022 Jul;50(7):957-967. doi: 10.1124/dmd.121.000818. Epub 2022 May 3. Drug Metab Dispos. 2022. PMID: 35504655
Influence of bile acids on the cytotoxicity of chemicals in cultivated human hepatocytes.
Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Zhang M, Gardner I, Marchan R, Ghallab A, Demirci Turgunbayer Ö, Rahnenführer J, Hengstler JG. Brecklinghaus T, et al. Among authors: zhang m. Toxicol In Vitro. 2022 Jun;81:105344. doi: 10.1016/j.tiv.2022.105344. Epub 2022 Mar 6. Toxicol In Vitro. 2022. PMID: 35263627
Prediction of human drug-induced liver injury (DILI) in relation to oral doses and blood concentrations.
Albrecht W, Kappenberg F, Brecklinghaus T, Stoeber R, Marchan R, Zhang M, Ebbert K, Kirschner H, Grinberg M, Leist M, Moritz W, Cadenas C, Ghallab A, Reinders J, Vartak N, van Thriel C, Golka K, Tolosa L, Castell JV, Damm G, Seehofer D, Lampen A, Braeuning A, Buhrke T, Behr AC, Oberemm A, Gu X, Kittana N, van de Water B, Kreiling R, Fayyaz S, van Aerts L, Smedsrød B, Ellinger-Ziegelbauer H, Steger-Hartmann T, Gundert-Remy U, Zeigerer A, Ullrich A, Runge D, Lee SML, Schiergens TS, Kuepfer L, Aguayo-Orozco A, Sachinidis A, Edlund K, Gardner I, Rahnenführer J, Hengstler JG. Albrecht W, et al. Among authors: zhang m. Arch Toxicol. 2019 Jun;93(6):1609-1637. doi: 10.1007/s00204-019-02492-9. Epub 2019 Jun 27. Arch Toxicol. 2019. PMID: 31250071
The hepatocyte export carrier inhibition assay improves the separation of hepatotoxic from non-hepatotoxic compounds.
Brecklinghaus T, Albrecht W, Kappenberg F, Duda J, Vartak N, Edlund K, Marchan R, Ghallab A, Cadenas C, Günther G, Leist M, Zhang M, Gardner I, Reinders J, Russel FG, Foster AJ, Williams DP, Damle-Vartak A, Grandits M, Ecker G, Kittana N, Rahnenführer J, Hengstler JG. Brecklinghaus T, et al. Among authors: zhang m. Chem Biol Interact. 2022 Jan 5;351:109728. doi: 10.1016/j.cbi.2021.109728. Epub 2021 Oct 27. Chem Biol Interact. 2022. PMID: 34717914 Free article.
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