Zhang L - Search Results

1

Structure-based design, synthesis, and evaluation of 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel c-Met inhibitors.

Zhang L, Zhang B, Zhao J, Zhi Y, Wang L, Lu T, Chen Y. Zhang L, et al. Among authors: zhang b. Eur J Med Chem. 2017 Sep 29;138:942-951. doi: 10.1016/j.ejmech.2017.06.057. Epub 2017 Jun 29. Eur J Med Chem. 2017. PMID: 28755635

2

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors.

Zhang Z, Hou S, Chen H, Ran T, Jiang F, Bian Y, Zhang D, Zhi Y, Wang L, Zhang L, Li H, Zhang Y, Tang W, Lu T, Chen Y. Zhang Z, et al. Among authors: zhang l, zhang d, zhang y. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2931-2935. doi: 10.1016/j.bmcl.2016.04.034. Epub 2016 Apr 22. Bioorg Med Chem Lett. 2016. PMID: 27142751

3

Design, synthesis and evaluation of derivatives based on pyrimidine scaffold as potent Pan-Raf inhibitors to overcome resistance.

Wang L, Zhang Q, Zhu G, Zhang Z, Zhi Y, Zhang L, Mao T, Zhou X, Chen Y, Lu T, Tang W. Wang L, et al. Among authors: zhang l, zhang q, zhang z. Eur J Med Chem. 2017 Apr 21;130:86-106. doi: 10.1016/j.ejmech.2017.02.041. Epub 2017 Feb 21. Eur J Med Chem. 2017. PMID: 28242553

4

Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors.

Yuan H, Liu Q, Zhang L, Hu S, Chen T, Li H, Chen Y, Xu Y, Lu T. Yuan H, et al. Among authors: zhang l. Eur J Med Chem. 2018 Jan 1;143:491-502. doi: 10.1016/j.ejmech.2017.11.073. Epub 2017 Dec 2. Eur J Med Chem. 2018. PMID: 29202410

5

Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia.

Wang Y, Zhi Y, Jin Q, Lu S, Lin G, Yuan H, Yang T, Wang Z, Yao C, Ling J, Guo H, Li T, Jin J, Li B, Zhang L, Chen Y, Lu T. Wang Y, et al. Among authors: zhang l. J Med Chem. 2018 Feb 22;61(4):1499-1518. doi: 10.1021/acs.jmedchem.7b01261. Epub 2018 Feb 12. J Med Chem. 2018. PMID: 29357250

6

Discovery of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazole derivatives as novel, potent and selective c-Met kinase inhibitors: Synthesis, SAR study, and biological activity.

Zhang L, Zhao J, Zhang B, Lu T, Chen Y. Zhang L, et al. Among authors: zhang b. Eur J Med Chem. 2018 Apr 25;150:809-816. doi: 10.1016/j.ejmech.2018.03.049. Epub 2018 Mar 21. Eur J Med Chem. 2018. PMID: 29602036

7

Insight into the key features for ligand binding in Y1230 mutated c-Met kinase domain by molecular dynamics simulations.

Yan L, Zhang L, Zhang Y, Qiao X, Pan J, Liu H, Lu S, Xiang B, Lu T, Yuan H. Yan L, et al. Among authors: zhang l, zhang y. J Biomol Struct Dyn. 2018 Jun;36(8):2015-2031. doi: 10.1080/07391102.2017.1340852. Epub 2017 Jun 20. J Biomol Struct Dyn. 2018. PMID: 28599617

8

Design, synthesis and evaluation of diosgenin carbamate derivatives as multitarget anti-Alzheimer's disease agents.

Yang GX, Huang Y, Zheng LL, Zhang L, Su L, Wu YH, Li J, Zhou LC, Huang J, Tang Y, Wang R, Ma L. Yang GX, et al. Among authors: zhang l. Eur J Med Chem. 2020 Feb 1;187:111913. doi: 10.1016/j.ejmech.2019.111913. Epub 2019 Nov 28. Eur J Med Chem. 2020. PMID: 31837501

9

Design and synthesis of novel artemisinin derivatives with potent activities against colorectal cancer in vitro and in vivo.

Wang LL, Kong L, Liu H, Zhang Y, Zhang L, Liu X, Yuan F, Li Y, Zuo Z. Wang LL, et al. Among authors: zhang l, zhang y. Eur J Med Chem. 2019 Nov 15;182:111665. doi: 10.1016/j.ejmech.2019.111665. Epub 2019 Aug 30. Eur J Med Chem. 2019. PMID: 31494469

10

Design and bio-evaluation of indole derivatives as potent Kv1.5 inhibitors.

Guo X, Yang Q, Xu J, Zhang L, Chu H, Yu P, Zhu Y, Wei J, Chen W, Zhang Y, Zhang X, Sun H, Tang Y, You Q. Guo X, et al. Among authors: zhang l, zhang x, zhang y. Bioorg Med Chem. 2013 Nov 1;21(21):6466-76. doi: 10.1016/j.bmc.2013.08.041. Epub 2013 Aug 31. Bioorg Med Chem. 2013. PMID: 24071446

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