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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism.
Murphy JM, Czabotar PE, Hildebrand JM, Lucet IS, Zhang JG, Alvarez-Diaz S, Lewis R, Lalaoui N, Metcalf D, Webb AI, Young SN, Varghese LN, Tannahill GM, Hatchell EC, Majewski IJ, Okamoto T, Dobson RC, Hilton DJ, Babon JJ, Nicola NA, Strasser A, Silke J, Alexander WS. Murphy JM, et al. Among authors: zhang jg. Immunity. 2013 Sep 19;39(3):443-53. doi: 10.1016/j.immuni.2013.06.018. Epub 2013 Sep 5. Immunity. 2013. PMID: 24012422 Free article.
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Krebs DL, Uren RT, Metcalf D, Rakar S, Zhang JG, Starr R, De Souza DP, Hanzinikolas K, Eyles J, Connolly LM, Simpson RJ, Nicola NA, Nicholson SE, Baca M, Hilton DJ, Alexander WS. Krebs DL, et al. Among authors: zhang jg. Mol Cell Biol. 2002 Jul;22(13):4567-78. doi: 10.1128/MCB.22.13.4567-4578.2002. Mol Cell Biol. 2002. PMID: 12052866 Free PMC article.
SOCS3 negatively regulates IL-6 signaling in vivo.
Croker BA, Krebs DL, Zhang JG, Wormald S, Willson TA, Stanley EG, Robb L, Greenhalgh CJ, Förster I, Clausen BE, Nicola NA, Metcalf D, Hilton DJ, Roberts AW, Alexander WS. Croker BA, et al. Among authors: zhang jg. Nat Immunol. 2003 Jun;4(6):540-5. doi: 10.1038/ni931. Epub 2003 May 18. Nat Immunol. 2003. PMID: 12754505
Development of hydrocephalus in mice lacking SOCS7.
Krebs DL, Metcalf D, Merson TD, Voss AK, Thomas T, Zhang JG, Rakar S, O'bryan MK, Willson TA, Viney EM, Mielke LA, Nicola NA, Hilton DJ, Alexander WS. Krebs DL, et al. Among authors: zhang jg. Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15446-51. doi: 10.1073/pnas.0406870101. Epub 2004 Oct 19. Proc Natl Acad Sci U S A. 2004. PMID: 15494444 Free PMC article.
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
Nicholson SE, Metcalf D, Sprigg NS, Columbus R, Walker F, Silva A, Cary D, Willson TA, Zhang JG, Hilton DJ, Alexander WS, Nicola NA. Nicholson SE, et al. Among authors: zhang jg. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2328-33. doi: 10.1073/pnas.0409675102. Epub 2005 Feb 3. Proc Natl Acad Sci U S A. 2005. PMID: 15695332 Free PMC article.
1,314 results