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Asparagine restriction enhances CD8+ T cell metabolic fitness and antitumoral functionality through an NRF2-dependent stress response.
Gnanaprakasam JNR, Kushwaha B, Liu L, Chen X, Kang S, Wang T, Cassel TA, Adams CM, Higashi RM, Scott DA, Xin G, Li Z, Yang J, Lane AN, Fan TW, Zhang J, Wang R. Gnanaprakasam JNR, et al. Among authors: zhang j. Nat Metab. 2023 Aug;5(8):1423-1439. doi: 10.1038/s42255-023-00856-1. Epub 2023 Aug 7. Nat Metab. 2023. PMID: 37550596 Free PMC article.
Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells.
Halbrook CJ, Thurston G, Boyer S, Anaraki C, Jiménez JA, McCarthy A, Steele NG, Kerk SA, Hong HS, Lin L, Law FV, Felton C, Scipioni L, Sajjakulnukit P, Andren A, Beutel AK, Singh R, Nelson BS, Van Den Bergh F, Krall AS, Mullen PJ, Zhang L, Batra S, Morton JP, Stanger BZ, Christofk HR, Digman MA, Beard DA, Viale A, Zhang J, Crawford HC, Pasca di Magliano M, Jorgensen C, Lyssiotis CA. Halbrook CJ, et al. Among authors: zhang l, zhang j. Nat Cancer. 2022 Nov;3(11):1386-1403. doi: 10.1038/s43018-022-00463-1. Epub 2022 Nov 21. Nat Cancer. 2022. PMID: 36411320 Free PMC article.
Asparagine bioavailability regulates the translation of MYC oncogene.
Srivastava S, Jiang J, Misra J, Seim G, Staschke KA, Zhong M, Zhou L, Liu Y, Chen C, Davé U, Kapur R, Batra S, Zhang C, Zhou J, Fan J, Wek RC, Zhang J. Srivastava S, et al. Among authors: zhang c, zhang j. Oncogene. 2022 Oct;41(44):4855-4865. doi: 10.1038/s41388-022-02474-9. Epub 2022 Oct 1. Oncogene. 2022. PMID: 36182969 Free PMC article.
Asparagine: A Metabolite to Be Targeted in Cancers.
Jiang J, Batra S, Zhang J. Jiang J, et al. Among authors: zhang j. Metabolites. 2021 Jun 19;11(6):402. doi: 10.3390/metabo11060402. Metabolites. 2021. PMID: 34205460 Free PMC article. Review.
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