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USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy.
Xiong W, Gao X, Zhang T, Jiang B, Hu MM, Bu X, Gao Y, Zhang LZ, Xiao BL, He C, Sun Y, Li H, Shi J, Xiao X, Xiang B, Xie C, Chen G, Zhang H, Wei W, Freeman GJ, Shu HB, Wang H, Zhang J. Xiong W, et al. Among authors: zhang lz, zhang t, zhang j, zhang h. Nat Commun. 2022 Mar 31;13(1):1700. doi: 10.1038/s41467-022-29401-6. Nat Commun. 2022. PMID: 35361799 Free PMC article.
ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy.
Xiao X, Shi J, He C, Bu X, Sun Y, Gao M, Xiang B, Xiong W, Dai P, Mao Q, Xing X, Yao Y, Yu H, Xu G, Li S, Ren Y, Chen B, Jiang C, Meng G, Lee YR, Wei W, Freeman GJ, Xie C, Zhang J. Xiao X, et al. Among authors: zhang j. Nat Commun. 2023 May 19;14(1):2859. doi: 10.1038/s41467-023-38605-3. Nat Commun. 2023. PMID: 37208329 Free PMC article.
USP8-governed GPX4 homeostasis orchestrates ferroptosis and cancer immunotherapy.
Li H, Sun Y, Yao Y, Ke S, Zhang N, Xiong W, Shi J, He C, Xiao X, Yu H, Dai P, Xiang B, Xing X, Xu G, Song W, Song J, Zhang J. Li H, et al. Among authors: zhang n, zhang j. Proc Natl Acad Sci U S A. 2024 Apr 16;121(16):e2315541121. doi: 10.1073/pnas.2315541121. Epub 2024 Apr 10. Proc Natl Acad Sci U S A. 2024. PMID: 38598341
Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy.
Yu H, Liu J, Bu X, Ma Z, Yao Y, Li J, Zhang T, Song W, Xiao X, Sun Y, Xiong W, Shi J, Dai P, Xiang B, Duan H, Yan X, Wu F, Zhang WC, Lin D, Hu H, Zhang H, Slack FJ, He HH, Freeman GJ, Wei W, Zhang J. Yu H, et al. Among authors: zhang t, zhang wc, zhang j, zhang h. Cell Chem Biol. 2024 Apr 18;31(4):776-791.e7. doi: 10.1016/j.chembiol.2023.09.001. Epub 2023 Sep 25. Cell Chem Biol. 2024. PMID: 37751743
Prostate cancer-associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4.
Dai X, Gan W, Li X, Wang S, Zhang W, Huang L, Liu S, Zhong Q, Guo J, Zhang J, Chen T, Shimizu K, Beca F, Blattner M, Vasudevan D, Buckley DL, Qi J, Buser L, Liu P, Inuzuka H, Beck AH, Wang L, Wild PJ, Garraway LA, Rubin MA, Barbieri CE, Wong KK, Muthuswamy SK, Huang J, Chen Y, Bradner JE, Wei W. Dai X, et al. Among authors: zhang w, zhang j. Nat Med. 2017 Sep;23(9):1063-1071. doi: 10.1038/nm.4378. Epub 2017 Aug 14. Nat Med. 2017. PMID: 28805820 Free PMC article.
164,954 results
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