Zhang J - Search Results

1

Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.

Blum E, Zhang J, Zaluski J, Einstein DE, Korshin EE, Kubas A, Gruzman A, Tochtrop GP, Kiser PD, Palczewski K. Blum E, et al. Among authors: zhang j. J Med Chem. 2021 Jun 24;64(12):8287-8302. doi: 10.1021/acs.jmedchem.1c00279. Epub 2021 Jun 3. J Med Chem. 2021. PMID: 34081480 Free PMC article.

2

Catabolism of 4-hydroxyacids and 4-hydroxynonenal via 4-hydroxy-4-phosphoacyl-CoAs.

Zhang GF, Kombu RS, Kasumov T, Han Y, Sadhukhan S, Zhang J, Sayre LM, Ray D, Gibson KM, Anderson VA, Tochtrop GP, Brunengraber H. Zhang GF, et al. Among authors: zhang j. J Biol Chem. 2009 Nov 27;284(48):33521-34. doi: 10.1074/jbc.M109.055665. Epub 2009 Sep 15. J Biol Chem. 2009. PMID: 19759021 Free PMC article.

3

Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal.

Zhu X, Tang X, Zhang J, Tochtrop GP, Anderson VE, Sayre LM. Zhu X, et al. Among authors: zhang j. Chem Res Toxicol. 2010 Mar 15;23(3):467-73. doi: 10.1021/tx900379a. Chem Res Toxicol. 2010. PMID: 20070074 Free PMC article.

4

Inherent instability of the retinitis pigmentosa P23H mutant opsin.

Chen Y, Jastrzebska B, Cao P, Zhang J, Wang B, Sun W, Yuan Y, Feng Z, Palczewski K. Chen Y, et al. Among authors: zhang j. J Biol Chem. 2014 Mar 28;289(13):9288-303. doi: 10.1074/jbc.M114.551713. Epub 2014 Feb 10. J Biol Chem. 2014. PMID: 24515108 Free PMC article.

5

Identification and characterization of novel inhibitors of Mammalian aspartyl aminopeptidase.

Chen Y, Tang H, Seibel W, Papoian R, Oh K, Li X, Zhang J, Golczak M, Palczewski K, Kiser PD. Chen Y, et al. Among authors: zhang j. Mol Pharmacol. 2014 Aug;86(2):231-42. doi: 10.1124/mol.114.093070. Epub 2014 Jun 9. Mol Pharmacol. 2014. PMID: 24913940 Free PMC article.

6

Expansion of first-in-class drug candidates that sequester toxic all-trans-retinal and prevent light-induced retinal degeneration.

Zhang J, Dong Z, Mundla SR, Hu XE, Seibel W, Papoian R, Palczewski K, Golczak M. Zhang J, et al. Mol Pharmacol. 2015;87(3):477-91. doi: 10.1124/mol.114.096560. Epub 2014 Dec 23. Mol Pharmacol. 2015. PMID: 25538117 Free PMC article.

7

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision.

Kiser PD, Zhang J, Badiee M, Li Q, Shi W, Sui X, Golczak M, Tochtrop GP, Palczewski K. Kiser PD, et al. Among authors: zhang j. Nat Chem Biol. 2015 Jun;11(6):409-15. doi: 10.1038/nchembio.1799. Epub 2015 Apr 20. Nat Chem Biol. 2015. PMID: 25894083 Free PMC article.

8

Molecular pharmacodynamics of emixustat in protection against retinal degeneration.

Zhang J, Kiser PD, Badiee M, Palczewska G, Dong Z, Golczak M, Tochtrop GP, Palczewski K. Zhang J, et al. J Clin Invest. 2015 Jul 1;125(7):2781-94. doi: 10.1172/JCI80950. Epub 2015 Jun 15. J Clin Invest. 2015. PMID: 26075817 Free PMC article.

9

Utilization of Dioxygen by Carotenoid Cleavage Oxygenases.

Sui X, Golczak M, Zhang J, Kleinberg KA, von Lintig J, Palczewski K, Kiser PD. Sui X, et al. Among authors: zhang j. J Biol Chem. 2015 Dec 18;290(51):30212-23. doi: 10.1074/jbc.M115.696799. Epub 2015 Oct 23. J Biol Chem. 2015. PMID: 26499794 Free PMC article.

10

Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase.

Sui X, Zhang J, Golczak M, Palczewski K, Kiser PD. Sui X, et al. Among authors: zhang j. J Biol Chem. 2016 Sep 9;291(37):19401-12. doi: 10.1074/jbc.M116.744912. Epub 2016 Jul 24. J Biol Chem. 2016. PMID: 27453555 Free PMC article.

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