Cytochrome b5 inhibits electron transfer from NADPH-cytochrome P450 reductase to ferric cytochrome P450 2B4.
Zhang H, Hamdane D, Im SC, Waskell L.
Zhang H, et al.
J Biol Chem. 2008 Feb 29;283(9):5217-25. doi: 10.1074/jbc.M709094200. Epub 2007 Dec 17.
J Biol Chem. 2008.
PMID: 18086668
Free article.
Experiments demonstrating that cytochrome (cyt) b5 inhibits the activity of cytochrome P450 2B4 (cyt P450 2B4) at higher concentrations suggested that cyt b5 was occupying the cyt P450 reductase-binding site on cyt P450 2B4 and preventing the reduction of ferric cyt P450 (Zhan …
Experiments demonstrating that cytochrome (cyt) b5 inhibits the activity of cytochrome P450 2B4 (cyt P450 2B4) at higher concentrations sugg …