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A cell-penetrating helical peptide as a potential HIV-1 inhibitor.
Zhang H, Zhao Q, Bhattacharya S, Waheed AA, Tong X, Hong A, Heck S, Curreli F, Goger M, Cowburn D, Freed EO, Debnath AK. Zhang H, et al. J Mol Biol. 2008 May 2;378(3):565-80. doi: 10.1016/j.jmb.2008.02.066. Epub 2008 Mar 6. J Mol Biol. 2008. PMID: 18374356 Free PMC article.
Solution structure of a hydrocarbon stapled peptide inhibitor in complex with monomeric C-terminal domain of HIV-1 capsid.
Bhattacharya S, Zhang H, Debnath AK, Cowburn D. Bhattacharya S, et al. Among authors: zhang h. J Biol Chem. 2008 Jun 13;283(24):16274-8. doi: 10.1074/jbc.C800048200. Epub 2008 Apr 16. J Biol Chem. 2008. PMID: 18417468 Free PMC article.
In a previous study, we characterized the binding affinity of a hydrocarbon stapled helical peptide, NYAD-1, for the capsid protein (K(d) approximately 1 mum) and demonstrated its ability to penetrate the cell membrane (Zhang, H., Zhao, Q., Bhattacharya, S., Waheed, …
In a previous study, we characterized the binding affinity of a hydrocarbon stapled helical peptide, NYAD-1, for the capsid protein (K(d) ap …
Dual-acting stapled peptides target both HIV-1 entry and assembly.
Zhang H, Curreli F, Waheed AA, Mercredi PY, Mehta M, Bhargava P, Scacalossi D, Tong X, Lee S, Cooper A, Summers MF, Freed EO, Debnath AK. Zhang H, et al. Retrovirology. 2013 Nov 15;10:136. doi: 10.1186/1742-4690-10-136. Retrovirology. 2013. PMID: 24237936 Free PMC article.
Novel structures of self-associating stapled peptides.
Bhattacharya S, Zhang H, Cowburn D, Debnath AK. Bhattacharya S, et al. Among authors: zhang h. Biopolymers. 2012 May;97(5):253-64. doi: 10.1002/bip.22015. Epub 2011 Dec 14. Biopolymers. 2012. PMID: 22170623 Free PMC article.
Design of antiviral stapled peptides containing a biphenyl cross-linker.
Muppidi A, Zhang H, Curreli F, Li N, Debnath AK, Lin Q. Muppidi A, et al. Among authors: zhang h. Bioorg Med Chem Lett. 2014 Apr 1;24(7):1748-51. doi: 10.1016/j.bmcl.2014.02.038. Epub 2014 Feb 22. Bioorg Med Chem Lett. 2014. PMID: 24613163 Free PMC article.
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