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Inhibition of HSD17B13 protects against liver fibrosis by inhibition of pyrimidine catabolism in nonalcoholic steatohepatitis.
Luukkonen PK, Sakuma I, Gaspar RC, Mooring M, Nasiri A, Kahn M, Zhang XM, Zhang D, Sammalkorpi H, Penttilä AK, Orho-Melander M, Arola J, Juuti A, Zhang X, Yimlamai D, Yki-Järvinen H, Petersen KF, Shulman GI. Luukkonen PK, et al. Among authors: zhang xm, zhang d, zhang x. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2217543120. doi: 10.1073/pnas.2217543120. Epub 2023 Jan 20. Proc Natl Acad Sci U S A. 2023. PMID: 36669104 Free PMC article.
Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease.
Kumashiro N, Erion DM, Zhang D, Kahn M, Beddow SA, Chu X, Still CD, Gerhard GS, Han X, Dziura J, Petersen KF, Samuel VT, Shulman GI. Kumashiro N, et al. Among authors: zhang d. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16381-5. doi: 10.1073/pnas.1113359108. Epub 2011 Sep 19. Proc Natl Acad Sci U S A. 2011. PMID: 21930939 Free PMC article.
Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.
Choi CS, Befroy DE, Codella R, Kim S, Reznick RM, Hwang YJ, Liu ZX, Lee HY, Distefano A, Samuel VT, Zhang D, Cline GW, Handschin C, Lin J, Petersen KF, Spiegelman BM, Shulman GI. Choi CS, et al. Among authors: zhang d. Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19926-31. doi: 10.1073/pnas.0810339105. Epub 2008 Dec 9. Proc Natl Acad Sci U S A. 2008. PMID: 19066218 Free PMC article.
Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance.
Lee HY, Birkenfeld AL, Jornayvaz FR, Jurczak MJ, Kanda S, Popov V, Frederick DW, Zhang D, Guigni B, Bharadwaj KG, Choi CS, Goldberg IJ, Park JH, Petersen KF, Samuel VT, Shulman GI. Lee HY, et al. Among authors: zhang d. Hepatology. 2011 Nov;54(5):1650-60. doi: 10.1002/hep.24571. Epub 2011 Aug 19. Hepatology. 2011. PMID: 21793029 Free PMC article.
CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance.
Cantley JL, Yoshimura T, Camporez JP, Zhang D, Jornayvaz FR, Kumashiro N, Guebre-Egziabher F, Jurczak MJ, Kahn M, Guigni BA, Serr J, Hankin J, Murphy RC, Cline GW, Bhanot S, Manchem VP, Brown JM, Samuel VT, Shulman GI. Cantley JL, et al. Among authors: zhang d. Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):1869-74. doi: 10.1073/pnas.1219456110. Epub 2013 Jan 9. Proc Natl Acad Sci U S A. 2013. PMID: 23302688 Free PMC article.
Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo.
Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI. Galbo T, et al. Among authors: zhang d. Proc Natl Acad Sci U S A. 2013 Jul 30;110(31):12780-5. doi: 10.1073/pnas.1311176110. Epub 2013 Jul 9. Proc Natl Acad Sci U S A. 2013. PMID: 23840067 Free PMC article.
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