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Biotransformation novel advances - 2021 year in review.
Khojasteh SC, Argikar UA, Cho S, Crouch R, Heck CJS, Johnson KM, Kalgutkar AS, King L, Maw HH, Seneviratne HK, Wang S, Wei C, Zhang D, Jackson KD. Khojasteh SC, et al. Among authors: zhang d. Drug Metab Rev. 2022 Aug;54(3):207-245. doi: 10.1080/03602532.2022.2097253. Epub 2022 Aug 30. Drug Metab Rev. 2022. PMID: 35815654 Free PMC article. Review.
Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.
Zhang D, Pillow TH, Ma Y, Cruz-Chuh JD, Kozak KR, Sadowsky JD, Lewis Phillips GD, Guo J, Darwish M, Fan P, Chen J, He C, Wang T, Yao H, Xu Z, Chen J, Wai J, Pei Z, Hop CE, Khojasteh SC, Dragovich PS. Zhang D, et al. ACS Med Chem Lett. 2016 Aug 26;7(11):988-993. doi: 10.1021/acsmedchemlett.6b00233. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882196 Free PMC article.
Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads.
Zhang D, Le H, Cruz-Chuh JD, Bobba S, Guo J, Staben L, Zhang C, Ma Y, Kozak KR, Lewis Phillips GD, Vollmar BS, Sadowsky JD, Vandlen R, Wei B, Su D, Fan P, Dragovich PS, Khojasteh SC, Hop CECA, Pillow TH. Zhang D, et al. Among authors: zhang c. Bioconjug Chem. 2018 Feb 21;29(2):267-274. doi: 10.1021/acs.bioconjchem.7b00576. Epub 2018 Feb 7. Bioconjug Chem. 2018. PMID: 29369629
A Novel Depurination Methodology to Assess DNA Alkylation of Chloro-Bis-Seco-Cyclopropylbenzoindoles Allowed for Comparison of Minor-Groove Reactivity.
Wang S, Chen B, Dragovich P, Pillow T, Staben L, Guo J, Su D, Zhang C, Bobba S, Ma Y, Wang J, Sangaraju D, Wei B, Phillips GL, Khojasteh C, Zhang D. Wang S, et al. Among authors: zhang c, zhang d. Drug Metab Dispos. 2019 May;47(5):547-555. doi: 10.1124/dmd.118.085209. Epub 2019 Mar 11. Drug Metab Dispos. 2019. PMID: 30858239
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