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A High-Throughput, High-Containment Human Primary Epithelial Airway Organ-on-Chip Platform for SARS-CoV-2 Therapeutic Screening.
Fisher CR, Mba Medie F, Luu RJ, Gaibler RB, Mulhern TJ, Miller CR, Zhang CJ, Rubio LD, Marr EE, Vijayakumar V, Gabriel EP, Lopez Quezada L, Zhang CH, Anderson KS, Jorgensen WL, Alladina JW, Medoff BD, Borenstein JT, Gard AL. Fisher CR, et al. Among authors: zhang cj, zhang ch. Cells. 2023 Nov 16;12(22):2639. doi: 10.3390/cells12222639. Cells. 2023. PMID: 37998374 Free PMC article.
Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2.
Ghahremanpour MM, Tirado-Rives J, Deshmukh M, Ippolito JA, Zhang CH, de Vaca IC, Liosi ME, Anderson KS, Jorgensen WL. Ghahremanpour MM, et al. Among authors: zhang ch. bioRxiv [Preprint]. 2020 Aug 28:2020.08.28.271957. doi: 10.1101/2020.08.28.271957. bioRxiv. 2020. PMID: 32869018 Free PMC article. Updated. Preprint.
Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2.
Ghahremanpour MM, Tirado-Rives J, Deshmukh M, Ippolito JA, Zhang CH, Cabeza de Vaca I, Liosi ME, Anderson KS, Jorgensen WL. Ghahremanpour MM, et al. Among authors: zhang ch. ACS Med Chem Lett. 2020 Oct 25;11(12):2526-2533. doi: 10.1021/acsmedchemlett.0c00521. eCollection 2020 Dec 10. ACS Med Chem Lett. 2020. PMID: 33324471 Free PMC article.
Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations.
Zhang CH, Stone EA, Deshmukh M, Ippolito JA, Ghahremanpour MM, Tirado-Rives J, Spasov KA, Zhang S, Takeo Y, Kudalkar SN, Liang Z, Isaacs F, Lindenbach B, Miller SJ, Anderson KS, Jorgensen WL. Zhang CH, et al. Among authors: zhang s. ACS Cent Sci. 2021 Mar 24;7(3):467-475. doi: 10.1021/acscentsci.1c00039. Epub 2021 Feb 22. ACS Cent Sci. 2021. PMID: 33786375 Free PMC article.
Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.
Zhang CH, Spasov KA, Reilly RA, Hollander K, Stone EA, Ippolito JA, Liosi ME, Deshmukh MG, Tirado-Rives J, Zhang S, Liang Z, Miller SJ, Isaacs F, Lindenbach BD, Anderson KS, Jorgensen WL. Zhang CH, et al. Among authors: zhang s. ACS Med Chem Lett. 2021 Jul 14;12(8):1325-1332. doi: 10.1021/acsmedchemlett.1c00326. eCollection 2021 Aug 12. ACS Med Chem Lett. 2021. PMID: 34408808 Free PMC article.
Proof-of-concept studies with a computationally designed Mpro inhibitor as a synergistic combination regimen alternative to Paxlovid.
Papini C, Ullah I, Ranjan AP, Zhang S, Wu Q, Spasov KA, Zhang C, Mothes W, Crawford JM, Lindenbach BD, Uchil PD, Kumar P, Jorgensen WL, Anderson KS. Papini C, et al. Proc Natl Acad Sci U S A. 2024 Apr 23;121(17):e2320713121. doi: 10.1073/pnas.2320713121. Epub 2024 Apr 15. Proc Natl Acad Sci U S A. 2024. PMID: 38621119 Free PMC article.
Chest pain with diffuse ST segment elevation.
Li Z, Min XW, He PG, Zhang CH. Li Z, et al. Among authors: zhang ch. BMJ. 2024 May 2;385:e078403. doi: 10.1136/bmj-2023-078403. BMJ. 2024. PMID: 38697642 No abstract available.
1,027 results