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Fructose-1,6-bisphosphatase is a nonenzymatic safety valve that curtails AKT activation to prevent insulin hyperresponsiveness.
Gu L, Zhu Y, Watari K, Lee M, Liu J, Perez S, Thai M, Mayfield JE, Zhang B, Cunha E Rocha K, Li F, Kim LC, Jones AC, Wierzbicki IH, Liu X, Newton AC, Kisseleva T, Lee JH, Ying W, Gonzalez DJ, Saltiel AR, Simon MC, Karin M. Gu L, et al. Among authors: zhang b. Cell Metab. 2023 Jun 6;35(6):1009-1021.e9. doi: 10.1016/j.cmet.2023.03.021. Epub 2023 Apr 20. Cell Metab. 2023. PMID: 37084733 Free PMC article.
OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance.
Yang Y, Li X, Luan HH, Zhang B, Zhang K, Nam JH, Li Z, Fu M, Munk A, Zhang D, Wang S, Liu Y, Albuquerque JP, Ong Q, Li R, Wang Q, Robert ME, Perry RJ, Chung D, Shulman GI, Yang X. Yang Y, et al. Among authors: zhang b, zhang d, zhang k. Proc Natl Acad Sci U S A. 2020 Jul 14;117(28):16616-16625. doi: 10.1073/pnas.1916121117. Epub 2020 Jun 29. Proc Natl Acad Sci U S A. 2020. PMID: 32601203 Free PMC article.
O-GlcNAc transferase suppresses necroptosis and liver fibrosis.
Zhang B, Li MD, Yin R, Liu Y, Yang Y, Mitchell-Richards KA, Nam JH, Li R, Wang L, Iwakiri Y, Chung D, Robert ME, Ehrlich BE, Bennett AM, Yu J, Nathanson MH, Yang X. Zhang B, et al. JCI Insight. 2019 Nov 1;4(21):e127709. doi: 10.1172/jci.insight.127709. JCI Insight. 2019. PMID: 31672932 Free PMC article.
O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth.
Singh JP, Qian K, Lee JS, Zhou J, Han X, Zhang B, Ong Q, Ni W, Jiang M, Ruan HB, Li MD, Zhang K, Ding Z, Lee P, Singh K, Wu J, Herzog RI, Kaech S, Wendel HG, Yates JR 3rd, Han W, Sherwin RS, Nie Y, Yang X. Singh JP, et al. Among authors: zhang b, zhang k. Oncogene. 2020 Jan;39(3):560-573. doi: 10.1038/s41388-019-0975-3. Epub 2019 Sep 9. Oncogene. 2020. PMID: 31501520 Free PMC article.
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