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TET2 guards against unchecked BATF3-induced CAR T cell expansion.
Jain N, Zhao Z, Feucht J, Koche R, Iyer A, Dobrin A, Mansilla-Soto J, Yang J, Zhan Y, Lopez M, Gunset G, Sadelain M. Jain N, et al. Among authors: zhan y. Nature. 2023 Mar;615(7951):315-322. doi: 10.1038/s41586-022-05692-z. Epub 2023 Feb 8. Nature. 2023. PMID: 36755094 Free PMC article.
Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis.
Radzisheuskaya A, Shliaha PV, Grinev VV, Shlyueva D, Damhofer H, Koche R, Gorshkov V, Kovalchuk S, Zhan Y, Rodriguez KL, Johnstone AL, Keogh MC, Hendrickson RC, Jensen ON, Helin K. Radzisheuskaya A, et al. Among authors: zhan y. Mol Cell. 2021 Apr 15;81(8):1749-1765.e8. doi: 10.1016/j.molcel.2021.02.012. Epub 2021 Mar 2. Mol Cell. 2021. PMID: 33657400 Free PMC article.
Comprehensive molecular characterization of lung tumors implicates AKT and MYC signaling in adenocarcinoma to squamous cell transdifferentiation.
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Allaj V, Manoj P, Shah NS, Chan JM, Ciampricotti M, Chow A, Offin M, Ray-Kirton J, Egger JD, Bhanot UK, Linkov I, Asher M, Roehrl MH, Ventura K, Qiu J, de Stanchina E, Chang JC, Rekhtman N, Houck-Loomis B, Koche RP, Yu HA, Sen T, Rudin CM. Quintanal-Villalonga A, et al. J Hematol Oncol. 2021 Oct 16;14(1):170. doi: 10.1186/s13045-021-01186-z. J Hematol Oncol. 2021. PMID: 34656143 Free PMC article.
Inhibition of XPO1 Sensitizes Small Cell Lung Cancer to First- and Second-Line Chemotherapy.
Quintanal-Villalonga A, Taniguchi H, Hao Y, Chow A, Zhan YA, Chavan SS, Uddin F, Allaj V, Manoj P, Shah NS, Chan JM, Offin M, Ciampricotti M, Ray-Kirton J, Egger J, Bhanot U, Linkov I, Asher M, Roehrl MH, Qiu J, de Stanchina E, Hollmann TJ, Koche RP, Sen T, Poirier JT, Rudin CM. Quintanal-Villalonga A, et al. Among authors: zhan ya. Cancer Res. 2022 Feb 1;82(3):472-483. doi: 10.1158/0008-5472.CAN-21-2964. Epub 2021 Nov 23. Cancer Res. 2022. PMID: 34815254 Free PMC article.
Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers.
Quintanal-Villalonga A, Durani V, Sabet A, Redin E, Kawasaki K, Shafer M, Karthaus WR, Zaidi S, Zhan YA, Manoj P, Sridhar H, Shah NS, Chow A, Bhanot UK, Linkov I, Asher M, Yu HA, Qiu J, de Stanchina E, Patel RA, Morrissey C, Haffner MC, Koche RP, Sawyers CL, Rudin CM. Quintanal-Villalonga A, et al. Sci Transl Med. 2023 Aug 2;15(707):eadf7006. doi: 10.1126/scitranslmed.adf7006. Epub 2023 Aug 2. Sci Transl Med. 2023. PMID: 37531417 Free PMC article.
Multiomic Analysis of Lung Tumors Defines Pathways Activated in Neuroendocrine Transformation.
Quintanal-Villalonga A, Taniguchi H, Zhan YA, Hasan MM, Chavan SS, Meng F, Uddin F, Manoj P, Donoghue MTA, Won HH, Chan JM, Ciampricotti M, Chow A, Offin M, Chang JC, Ray-Kirton J, Tischfield SE, Egger J, Bhanot UK, Linkov I, Asher M, Sinha S, Silber J, Iacobuzio-Donahue CA, Roehrl MH, Hollmann TJ, Yu HA, Qiu J, de Stanchina E, Baine MK, Rekhtman N, Poirier JT, Loomis B, Koche RP, Rudin CM, Sen T. Quintanal-Villalonga A, et al. Cancer Discov. 2021 Dec 1;11(12):3028-3047. doi: 10.1158/2159-8290.CD-20-1863. Cancer Discov. 2021. PMID: 34155000 Free PMC article.
Targeting Lysine-Specific Demethylase 1 Rescues Major Histocompatibility Complex Class I Antigen Presentation and Overcomes Programmed Death-Ligand 1 Blockade Resistance in SCLC.
Nguyen EM, Taniguchi H, Chan JM, Zhan YA, Chen X, Qiu J, de Stanchina E, Allaj V, Shah NS, Uddin F, Manoj P, Liu M, Cai SF, Levine R, Quintanal-Villalonga Á, Sen T, Chow A, Rudin CM. Nguyen EM, et al. J Thorac Oncol. 2022 Aug;17(8):1014-1031. doi: 10.1016/j.jtho.2022.05.014. Epub 2022 Jun 9. J Thorac Oncol. 2022. PMID: 35691495 Free PMC article.
WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC.
Taniguchi H, Caeser R, Chavan SS, Zhan YA, Chow A, Manoj P, Uddin F, Kitai H, Qu R, Hayatt O, Shah NS, Quintanal Villalonga Á, Allaj V, Nguyen EM, Chan J, Michel AO, Mukae H, de Stanchina E, Rudin CM, Sen T. Taniguchi H, et al. Cell Rep. 2022 May 17;39(7):110814. doi: 10.1016/j.celrep.2022.110814. Cell Rep. 2022. PMID: 35584676 Free PMC article.
4,275 results