Zewe JP - Search Results

1

The DREAM complex mediates GIST cell quiescence and is a novel therapeutic target to enhance imatinib-induced apoptosis.

Boichuk S, Parry JA, Makielski KR, Litovchick L, Baron JL, Zewe JP, Wozniak A, Mehalek KR, Korzeniewski N, Seneviratne DS, Schöffski P, Debiec-Rychter M, DeCaprio JA, Duensing A. Boichuk S, et al. Among authors: zewe jp. Cancer Res. 2013 Aug 15;73(16):5120-9. doi: 10.1158/0008-5472.CAN-13-0579. Epub 2013 Jun 20. Cancer Res. 2013. PMID: 23786773

2

CLT1 targets bladder cancer through integrin α5β1 and CLIC3.

Knowles LM, Zewe J, Malik G, Parwani AV, Gingrich JR, Pilch J. Knowles LM, et al. Mol Cancer Res. 2013 Feb;11(2):194-203. doi: 10.1158/1541-7786.MCR-12-0300. Epub 2012 Nov 30. Mol Cancer Res. 2013. PMID: 23204394 Free PMC article.

3

Unbiased compound screening identifies unexpected drug sensitivities and novel treatment options for gastrointestinal stromal tumors.

Boichuk S, Lee DJ, Mehalek KR, Makielski KR, Wozniak A, Seneviratne DS, Korzeniewski N, Cuevas R, Parry JA, Brown MF, Zewe J, Taguchi T, Kuan SF, Schöffski P, Debiec-Rychter M, Duensing A. Boichuk S, et al. Cancer Res. 2014 Feb 15;74(4):1200-13. doi: 10.1158/0008-5472.CAN-13-1955. Epub 2014 Jan 2. Cancer Res. 2014. PMID: 24385214

4

Probing the subcellular distribution of phosphatidylinositol reveals a surprising lack at the plasma membrane.

Zewe JP, Miller AM, Sangappa S, Wills RC, Goulden BD, Hammond GRV. Zewe JP, et al. J Cell Biol. 2020 Mar 2;219(3):e201906127. doi: 10.1083/jcb.201906127. J Cell Biol. 2020. PMID: 32211893 Free PMC article.

5

PI(4,5)P2 diffuses freely in the plasma membrane even within high-density effector protein complexes.

Pacheco J, Cassidy AC, Zewe JP, Wills RC, Hammond GRV. Pacheco J, et al. Among authors: zewe jp. J Cell Biol. 2023 Feb 6;222(2):e202204099. doi: 10.1083/jcb.202204099. Epub 2022 Nov 23. J Cell Biol. 2023. PMID: 36416724 Free PMC article.

6

A novel homeostatic mechanism tunes PI(4,5)P2-dependent signaling at the plasma membrane.

Wills RC, Doyle CP, Zewe JP, Pacheco J, Hansen SD, Hammond GRV. Wills RC, et al. Among authors: zewe jp. J Cell Sci. 2023 Aug 15;136(16):jcs261494. doi: 10.1242/jcs.261494. Epub 2023 Aug 29. J Cell Sci. 2023. PMID: 37534432 Free PMC article.

7

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes.

Willett R, Martina JA, Zewe JP, Wills R, Hammond GRV, Puertollano R. Willett R, et al. Among authors: zewe jp. Nat Commun. 2017 Nov 17;8(1):1580. doi: 10.1038/s41467-017-01871-z. Nat Commun. 2017. PMID: 29146937 Free PMC article.

8

SAC1 degrades its lipid substrate PtdIns4P in the endoplasmic reticulum to maintain a steep chemical gradient with donor membranes.

Zewe JP, Wills RC, Sangappa S, Goulden BD, Hammond GR. Zewe JP, et al. Elife. 2018 Feb 20;7:e35588. doi: 10.7554/eLife.35588. Elife. 2018. PMID: 29461204 Free PMC article.

9

PI(4,5)P₂ controls plasma membrane PI4P and PS levels via ORP5/8 recruitment to ER-PM contact sites.

Sohn M, Korzeniowski M, Zewe JP, Wills RC, Hammond GRV, Humpolickova J, Vrzal L, Chalupska D, Veverka V, Fairn GD, Boura E, Balla T. Sohn M, et al. Among authors: zewe jp. J Cell Biol. 2018 May 7;217(5):1797-1813. doi: 10.1083/jcb.201710095. Epub 2018 Feb 22. J Cell Biol. 2018. PMID: 29472386 Free PMC article.

10

A high-avidity biosensor reveals plasma membrane PI(3,4)P₂ is predominantly a class I PI3K signaling product.

Goulden BD, Pacheco J, Dull A, Zewe JP, Deiters A, Hammond GRV. Goulden BD, et al. Among authors: zewe jp. J Cell Biol. 2019 Mar 4;218(3):1066-1079. doi: 10.1083/jcb.201809026. Epub 2018 Dec 27. J Cell Biol. 2019. PMID: 30591513 Free PMC article.

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