Zetterberg FR - Search Results

1

Discovery and Optimization of the First Highly Effective and Orally Available Galectin-3 Inhibitors for Treatment of Fibrotic Disease.

Zetterberg FR, MacKinnon A, Brimert T, Gravelle L, Johnsson RE, Kahl-Knutson B, Leffler H, Nilsson UJ, Pedersen A, Peterson K, Roper JA, Schambye H, Slack RJ, Tantawi S. Zetterberg FR, et al. J Med Chem. 2022 Oct 13;65(19):12626-12638. doi: 10.1021/acs.jmedchem.2c00660. Epub 2022 Sep 26. J Med Chem. 2022. PMID: 36154172 Free PMC article.

2

Monosaccharide Derivatives with Low-Nanomolar Lectin Affinity and High Selectivity Based on Combined Fluorine-Amide, Phenyl-Arginine, Sulfur-π, and Halogen Bond Interactions.

Zetterberg FR, Peterson K, Johnsson RE, Brimert T, Håkansson M, Logan DT, Leffler H, Nilsson UJ. Zetterberg FR, et al. ChemMedChem. 2018 Jan 22;13(2):133-137. doi: 10.1002/cmdc.201700744. Epub 2018 Jan 15. ChemMedChem. 2018. PMID: 29194992

3

Systematic Tuning of Fluoro-galectin-3 Interactions Provides Thiodigalactoside Derivatives with Single-Digit nM Affinity and High Selectivity.

Peterson K, Kumar R, Stenström O, Verma P, Verma PR, Håkansson M, Kahl-Knutsson B, Zetterberg F, Leffler H, Akke M, Logan DT, Nilsson UJ. Peterson K, et al. J Med Chem. 2018 Feb 8;61(3):1164-1175. doi: 10.1021/acs.jmedchem.7b01626. Epub 2018 Jan 11. J Med Chem. 2018. PMID: 29284090 Free article.

4

Quinoline-galactose hybrids bind selectively with high affinity to a galectin-8 N-terminal domain.

Pal KB, Mahanti M, Huang X, Persson S, Sundin AP, Zetterberg FR, Oredsson S, Leffler H, Nilsson UJ. Pal KB, et al. Among authors: zetterberg fr. Org Biomol Chem. 2018 Aug 29;16(34):6295-6305. doi: 10.1039/c8ob01354c. Org Biomol Chem. 2018. PMID: 30117507

5

An Orally Active Galectin-3 Antagonist Inhibits Lung Adenocarcinoma Growth and Augments Response to PD-L1 Blockade.

Vuong L, Kouverianou E, Rooney CM, McHugh BJ, Howie SEM, Gregory CD, Forbes SJ, Henderson NC, Zetterberg FR, Nilsson UJ, Leffler H, Ford P, Pedersen A, Gravelle L, Tantawi S, Schambye H, Sethi T, MacKinnon AC. Vuong L, et al. Among authors: zetterberg fr. Cancer Res. 2019 Apr 1;79(7):1480-1492. doi: 10.1158/0008-5472.CAN-18-2244. Epub 2019 Jan 23. Cancer Res. 2019. PMID: 30674531

6

Human trophoblast requires galectin-3 for cell migration and invasion.

Bojić-Trbojević Ž, Jovanović Krivokuća M, Vilotić A, Kolundžić N, Stefanoska I, Zetterberg F, Nilsson UJ, Leffler H, Vićovac L. Bojić-Trbojević Ž, et al. Sci Rep. 2019 Feb 14;9(1):2136. doi: 10.1038/s41598-018-38374-w. Sci Rep. 2019. PMID: 30765738 Free PMC article.

7

Extracellular and intracellular small-molecule galectin-3 inhibitors.

Stegmayr J, Zetterberg F, Carlsson MC, Huang X, Sharma G, Kahl-Knutson B, Schambye H, Nilsson UJ, Oredsson S, Leffler H. Stegmayr J, et al. Sci Rep. 2019 Feb 18;9(1):2186. doi: 10.1038/s41598-019-38497-8. Sci Rep. 2019. PMID: 30778105 Free PMC article.

8

Aminopyrimidine-galactose hybrids are highly selective galectin-3 inhibitors.

Dahlqvist A, Zetterberg FR, Leffler H, Nilsson UJ. Dahlqvist A, et al. Among authors: zetterberg fr. Medchemcomm. 2019 May 13;10(6):913-925. doi: 10.1039/c9md00183b. eCollection 2019 Jun 1. Medchemcomm. 2019. PMID: 31303989 Free PMC article.

9

3-Substituted 1-Naphthamidomethyl-C-galactosyls Interact with Two Unique Sub-sites for High-Affinity and High-Selectivity Inhibition of Galectin-3.

Dahlqvist A, Mandal S, Peterson K, Håkansson M, Logan DT, Zetterberg FR, Leffler H, Nilsson UJ. Dahlqvist A, et al. Among authors: zetterberg fr. Molecules. 2019 Dec 12;24(24):4554. doi: 10.3390/molecules24244554. Molecules. 2019. PMID: 31842451 Free PMC article.

10

In Vivo Veritas: ¹⁸F-Radiolabeled Glycomimetics Allow Insights into the Pharmacological Fate of Galectin-3 Inhibitors.

Bratteby K, Torkelsson E, L'Estrade ET, Peterson K, Shalgunov V, Xiong M, Leffler H, Zetterberg FR, Olsson TG, Gillings N, Nilsson UJ, Herth MM, Erlandsson M. Bratteby K, et al. Among authors: zetterberg fr. J Med Chem. 2020 Jan 23;63(2):747-755. doi: 10.1021/acs.jmedchem.9b01692. Epub 2020 Jan 3. J Med Chem. 2020. PMID: 31846326

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