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Adriforant is a functional antagonist of histamine receptor 4 and attenuates itch and skin inflammation in mice.
Uluckan Ö, Bruno S, Wang Y, Wack N, Wilzopolski J, Goetschy JF, Delucis-Bronn C, Urban B, Fehlmann D, Stark H, Hauchard A, Roussel E, Kempf D, Kaupmann K, Raulf F, Bäumer W, Röhn TA, Zerwes HG. Uluckan Ö, et al. Among authors: zerwes hg. Eur J Pharmacol. 2023 Apr 15;945:175533. doi: 10.1016/j.ejphar.2023.175533. Epub 2023 Jan 21. Eur J Pharmacol. 2023. PMID: 36690055
Requirement of Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 Protease Activity for Fcγ Receptor-Induced Arthritis, but Not Fcγ Receptor-Mediated Platelet Elimination, in Mice.
Martin K, Touil R, Cvijetic G, Israel L, Kolb Y, Sarret S, Valeaux S, Degl'Innocenti E, Le Meur T, Caesar N, Bardet M, Beerli C, Zerwes HG, Kovarik J, Beltz K, Schlapbach A, Quancard J, Régnier CH, Bigaud M, Junt T, Wieczorek G, Isnardi I, Littlewood-Evans A, Bornancin F, Calzascia T. Martin K, et al. Among authors: zerwes hg. Arthritis Rheumatol. 2020 Jun;72(6):919-930. doi: 10.1002/art.41204. Epub 2020 Apr 26. Arthritis Rheumatol. 2020. PMID: 31943941
A CARD10-Dependent Tonic Signalosome Activates MALT1 Paracaspase and Regulates IL-17/TNF-α-Driven Keratinocyte Inflammation.
Israël L, Bardet M, Huppertz A, Mercado N, Ginster S, Unterreiner A, Schlierf A, Goetschy JF, Zerwes HG, Roth L, Kolbinger F, Bornancin F. Israël L, et al. Among authors: zerwes hg. J Invest Dermatol. 2018 Sep;138(9):2075-2079. doi: 10.1016/j.jid.2018.03.1503. Epub 2018 Mar 20. J Invest Dermatol. 2018. PMID: 29571942 Free article. No abstract available.
Orally bioavailable Syk inhibitors with activity in a rat PK/PD model.
Thoma G, Veenstra S, Strang R, Blanz J, Vangrevelinghe E, Berghausen J, Lee CC, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. Bioorg Med Chem Lett. 2015 Oct 15;25(20):4642-7. doi: 10.1016/j.bmcl.2015.08.037. Epub 2015 Aug 18. Bioorg Med Chem Lett. 2015. PMID: 26320624
Discovery and profiling of a selective and efficacious Syk inhibitor.
Thoma G, Smith AB, van Eis MJ, Vangrevelinghe E, Blanz J, Aichholz R, Littlewood-Evans A, Lee CC, Liu H, Zerwes HG. Thoma G, et al. Among authors: zerwes hg. J Med Chem. 2015 Feb 26;58(4):1950-63. doi: 10.1021/jm5018863. Epub 2015 Feb 9. J Med Chem. 2015. PMID: 25633741
57 results