Zengerle M - Search Results

1

Understanding and Improving the Membrane Permeability of VH032-Based PROTACs.

Klein VG, Townsend CE, Testa A, Zengerle M, Maniaci C, Hughes SJ, Chan KH, Ciulli A, Lokey RS. Klein VG, et al. Among authors: zengerle m. ACS Med Chem Lett. 2020 Jul 30;11(9):1732-1738. doi: 10.1021/acsmedchemlett.0c00265. eCollection 2020 Sep 10. ACS Med Chem Lett. 2020. PMID: 32939229 Free PMC article.

2

Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds.

Chan KH, Zengerle M, Testa A, Ciulli A. Chan KH, et al. Among authors: zengerle m. J Med Chem. 2018 Jan 25;61(2):504-513. doi: 10.1021/acs.jmedchem.6b01912. Epub 2017 Jun 22. J Med Chem. 2018. PMID: 28595007 Free PMC article.

3

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4.

Zengerle M, Chan KH, Ciulli A. Zengerle M, et al. ACS Chem Biol. 2015 Aug 21;10(8):1770-7. doi: 10.1021/acschembio.5b00216. Epub 2015 Jun 16. ACS Chem Biol. 2015. PMID: 26035625 Free PMC article.

4

New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition.

Baud MG, Lin-Shiao E, Zengerle M, Tallant C, Ciulli A. Baud MG, et al. Among authors: zengerle m. J Med Chem. 2016 Feb 25;59(4):1492-500. doi: 10.1021/acs.jmedchem.5b01135. Epub 2015 Oct 1. J Med Chem. 2016. PMID: 26367539 Free PMC article.

5

Chemical genetics approaches for selective intervention in epigenetics.

Runcie AC, Chan KH, Zengerle M, Ciulli A. Runcie AC, et al. Among authors: zengerle m. Curr Opin Chem Biol. 2016 Aug;33:186-94. doi: 10.1016/j.cbpa.2016.06.031. Epub 2016 Jul 14. Curr Opin Chem Biol. 2016. PMID: 27423045 Free PMC article. Review.

6

Structural basis of PROTAC cooperative recognition for selective protein degradation.

Gadd MS, Testa A, Lucas X, Chan KH, Chen W, Lamont DJ, Zengerle M, Ciulli A. Gadd MS, et al. Among authors: zengerle m. Nat Chem Biol. 2017 May;13(5):514-521. doi: 10.1038/nchembio.2329. Epub 2017 Mar 13. Nat Chem Biol. 2017. PMID: 28288108 Free PMC article.

7

Optimization of a "bump-and-hole" approach to allele-selective BET bromodomain inhibition.

Runcie AC, Zengerle M, Chan KH, Testa A, van Beurden L, Baud MGJ, Epemolu O, Ellis LCJ, Read KD, Coulthard V, Brien A, Ciulli A. Runcie AC, et al. Among authors: zengerle m. Chem Sci. 2018 Jan 24;9(9):2452-2468. doi: 10.1039/c7sc02536j. eCollection 2018 Mar 7. Chem Sci. 2018. PMID: 29732121 Free PMC article.

8

Chemical biology. A bump-and-hole approach to engineer controlled selectivity of BET bromodomain chemical probes.

Baud MGJ, Lin-Shiao E, Cardote T, Tallant C, Pschibul A, Chan KH, Zengerle M, Garcia JR, Kwan TT, Ferguson FM, Ciulli A. Baud MGJ, et al. Among authors: zengerle m. Science. 2014 Oct 31;346(6209):638-641. doi: 10.1126/science.1249830. Epub 2014 Oct 16. Science. 2014. PMID: 25323695 Free PMC article.

9

Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.

Fernandez-Alonso R, Davidson L, Hukelmann J, Zengerle M, Prescott AR, Lamond A, Ciulli A, Sapkota GP, Findlay GM. Fernandez-Alonso R, et al. Among authors: zengerle m. EMBO Rep. 2017 Jul;18(7):1108-1122. doi: 10.15252/embr.201643534. Epub 2017 Jun 6. EMBO Rep. 2017. PMID: 28588073 Free PMC article.

10

Real-Time Investigation of Sulfur Vacancy Generation and Passivation in Monolayer Molybdenum Disulfide via in situ X-ray Photoelectron Spectromicroscopy.

Grünleitner T, Henning A, Bissolo M, Zengerle M, Gregoratti L, Amati M, Zeller P, Eichhorn J, Stier AV, Holleitner AW, Finley JJ, Sharp ID. Grünleitner T, et al. Among authors: zengerle m. ACS Nano. 2022 Dec 27;16(12):20364-20375. doi: 10.1021/acsnano.2c06317. Epub 2022 Dec 14. ACS Nano. 2022. PMID: 36516326

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